Oxidoreductase HTATIP2 (EC 1.1.1.-) (30 kDa HIV-1 TAT-interacting protein) (HIV-1 TAT-interactive protein 2)
1_MAETE 6_ ALSKL 11_ REDFR 16_ MQNKS 21_ VFILG 26_ ASGET 31_ GRVLL 36_ KEILE 41_ QGLFS 46_ KVTLI 51_ GRRKL 56_ TFDEE 61_ AYKNV 66_ NQEVV 71_ DFEKL 76_ DDYAS 81_ AFQGH 86_ DVGFC 91_ CLGTT 96_ RGKAG 101_ AEGFV 106_ RVDRD 111_ YVLKS 116_ AELAK 121_ AGGCK 126_ HFNLL 131_ SSKGA 136_ DKSSN 141_ FLYLQ 146_ VKGEV 151_ EAKVE 156_ ELKFD 161_ RYSVF 166_ RPGVL 171_ LCDRQ 176_ ESRPG 181_ EWLVR 186_ KFFGS 191_ LPDSW 196_ ASGHS 201_ VPVVT 206_ VVRAM 211_ LNNVV 216_ RPRDK 221_ QMELL 226_ ENKAI 231_ HDLGK 236_AHGSL
1: Represses translation by preventing reactivation of elongation factor eEF1A (By similarity). May also inhibit nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors (PubMed:15282309). Has additionally been proposed to act as a redox sensor involved in cellular oxidative stress surveillance (PubMed:18519672)