Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD)
1_MAGEL 6_ ADKKD 11_ RDASP 16_ SKEER 21_ KRSRT 26_ PDRER 31_ DRDRD 36_ RKSSP 41_ SKDRK 46_ RHRSR 51_ DRRRG 56_ GSRSR 61_ SRSRS 66_ KSAER 71_ ERRHK 76_ ERERD 81_ KERDR 86_ NKKDR 91_ DRDKD 96_ GHRRD 101_ KDRKR 106_ SSLSP 111_ GRGKD 116_ FKSRK 121_ DRDSK 126_ KDEED 131_ EHGDK 136_ KPKAQ 141_ PLSLE 146_ ELLAK 151_ KKAEE 156_ EAEAK 161_ PKFLS 166_ KAERE 171_ AEALK 176_ RRQQE 181_ VEERQ 186_ RMLEE 191_ ERKKR 196_ KQFQD 201_ LGRKM 206_ LEDPQ 211_ ERERR 216_ ERRER 221_ MERET 226_ NGNED 231_ EEGRQ 236_ KIREE 241_ KDKSK 246_ ELHAI 251_ KERYL 256_ GGIKK 261_ RRRTR 266_ HLNDR 271_ KFVFE 276_ WDASE 281_ DTSID 286_ YNPLY 291_ KERHQ 296_ VQLLG 301_ RGFIA 306_ GIDLK 311_ QQKRE 316_ QSRFY 321_ GDLME 326_ KRRTL 331_ EEKEQ 336_ EEARL 341_ RKLRK 346_ KEAKQ 351_ RWDDR 356_ HWSQK 361_ KLDEM 366_ TDRDW 371_ RIFRE 376_ DYSIT 381_ TKGGK 386_ IPNPI 391_ RSWKD 396_ SSLPP 401_ HILEV 406_ IDKCG 411_ YKEPT 416_ PIQRQ 421_ AIPIG 426_ LQNRD 431_ IIGVA 436_ ETGSG 441_ KTAAF 446_ LIPLL 451_ VWITT 456_ LPKID 461_ RIEES 466_ DQGPY 471_ AIILA 476_ PTREL 481_ AQQIE 486_ EETIK 491_ FGKPL 496_ GIRTV 501_ AVIGG 506_ ISRED 511_ QGFRL 516_ RMGCE 521_ IVIAT 526_ PGRLI 531_ DVLEN 536_ RYLVL 541_ SRCTY 546_ VVLDE 551_ ADRMI 556_ DMGFE 561_ PDVQK 566_ ILEHM 571_ PVSNQ 576_ KPDTD 581_ EAEDP 586_ EKMLA 591_ NFESG 596_ KHKYR 601_ QTVMF 606_ TATMP 611_ PAVER 616_ LARSY 621_ LRRPA 626_ VVYIG 631_ SAGKP 636_ HERVE 641_ QKVFL 646_ MSESE 651_ KRKKL 656_ LAILE 661_ QGFDP 666_ PIIIF 671_ VNQKK 676_ GCDVL 681_ AKSLE 686_ KMGYN 691_ ACTLH 696_ GGKGQ 701_ EQREF 706_ ALSNL 711_ KAGAK 716_ DILVA 721_ TDVAG 726_ RGIDI 731_ QDVSM 736_ VVNYD 741_ MAKNI 746_ EDYIH 751_ RIGRT 756_ GRAGK 761_ SGVAI 766_ TFLTK 771_ EDSAV 776_ FYELK 781_ QAILE 786_ SPVSS 791_ CPPEL 796_ ANHPD 801_ AQHKP 806_ GTILT 811_KKRRE
1: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779)