Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta)
1_MKTLE 6_ TQPLA 11_ PDCCP 16_ SDQDP 21_ APAHP 26_ SPHAS 31_ PMNKN 36_ ADSEL 41_ MPPPP 46_ ERGDP 51_ PRLSP 56_ DPVAG 61_ SAVSQ 66_ ELREG 71_ DPVSL 76_ STPLE 81_ TEFGS 86_ PSELS 91_ PRIEE 96_ QELSE 101_ NTSLP 106_ AEEAN 111_ GSLSE 116_ EEANG 121_ PELGS 126_ GKAME 131_ DTSGE 136_ PAAED 141_ EGDTA 146_ WNYSF 151_ SQLPR 156_ FLSGS 161_ WSEFS 166_ TQPEN 171_ FLKGC 176_ KWAPD 181_ GSCIL 186_ TNSAD 191_ NILRI 196_ YNLPP 201_ ELYHE 206_ GEQVE 211_ YAEMV 216_ PVLRM 221_ VEGDT 226_ IYDYC 231_ WYSLM 236_ SSAQP 241_ DTSYV 246_ ASSSR 251_ ENPIH 256_ IWDAF 261_ TGELR 266_ ASFRA 271_ YNHLD 276_ ELTAA 281_ HSLCF 286_ SPDGS 291_ QLFCG 296_ FNRTV 301_ RVFST 306_ ARPGR 311_ DCEVR 316_ ATFAK 321_ KQGQS 326_ GIISC 331_ IAFSP 336_ AQPLY 341_ ACGSY 346_ GRSLG 351_ LYAWD 356_ DGSPL 361_ ALLGG 366_ HQGGI 371_ THLCF 376_ HPDGN 381_ RFFSG 386_ ARKDA 391_ ELLCW 396_ DLRQS 401_ GYPLW 406_ SLGRE 411_ VTTNQ 416_ RIYFD 421_ LDPTG 426_ QFLVS 431_ GSTSG 436_ AVSVW 441_ DTDGP 446_ GNDGK 451_ PEPVL 456_ SFLPQ 461_ KDCTN 466_ GVSLH 471_ PSLPL 476_ LATAS 481_ GQRVF 486_ PEPTE 491_ SGDEG 496_ EELGL 501_ PLLST 506_ RHVHL 511_ ECRLQ 516_ LWWCG 521_ GAPDS 526_ SIPDD 531_ HQGEK 536_ GQGGT 541_EGGVG
1: RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29695869, PubMed:29804836). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29695869, PubMed:29804836). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to Cajal body (PubMed:22547674). During S phase, required for delivery of TERC to telomeres during S phase and for telomerase activity (PubMed:29804836). In addition to its role in telomere maintenance, also required for Cajal body formation, probably by mediating localization of scaRNAs to Cajal bodies (PubMed:19285445, PubMed:21072240). Also plays a role in DNA repair: phosphorylated by ATM in response to DNA damage and relocalizes to sites of DNA double-strand breaks to promote the repair of DNA double-strand breaks (PubMed:25512560, PubMed:27715493). Acts by recruiting the ubiquitin ligase RNF8 to DNA breaks and promote both homologous recombination (HR) and non-homologous end joining (NHEJ) (PubMed:25512560, PubMed:27715493)