MICOS complex subunit MIC26 (Apolipoprotein O) (MICOS complex subunit MIC23) (Protein FAM121B)
1_MFKVI 6_ QRSVG 11_ PASLS 16_ LLTFK 21_ VYAAP 26_ KKDSP 31_ PKNSV 36_ KVDEL 41_ SLYSV 46_ PEGQS 51_ KYVEE 56_ ARSQL 61_ EESIS 66_ QLRHY 71_ CEPYT 76_ TWCQE 81_ TYSQT 86_ KPKMQ 91_ SLVQW 96_ GLDSY 101_ DYLQN 106_ APPGF 111_ FPRLG 116_ VIGFA 121_ GLIGL 126_ LLARG 131_ SKIKK 136_ LVYPP 141_ GFMGL 146_ AASLY 151_ YPQQA 156_ IVFAQ 161_ VSGER 166_ LYDWG 171_ LRGYI 176_ VIEDL 181_ WKENF 186_ QKPGN 191_VKNSP
1: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892)