3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.-) (EC 1.1.1.30) (Dehydrogenase/reductase SDR family member 6) (Oxidoreductase UCPA) (R-beta-hydroxybutyrate dehydrogenase) (Short chain dehydrogenase/reductase family 15C member 1)
1_MGRLD 6_ GKVII 11_ LTAAA 16_ QGIGQ 21_ AAALA 26_ FAREG 31_ AKVIA 36_ TDINE 41_ SKLQE 46_ LEKYP 51_ GIQTR 56_ VLDVT 61_ KKKQI 66_ DQFAN 71_ EVERL 76_ DVLFN 81_ VAGFV 86_ HHGTV 91_ LDCEE 96_ KDWDF 101_ SMNLN 106_ VRSMY 111_ LMIKA 116_ FLPKM 121_ LAQKS 126_ GNIIN 131_ MSSVA 136_ SSVKG 141_ VVNRC 146_ VYSTT 151_ KAAVI 156_ GLTKS 161_ VAADF 166_ IQQGI 171_ RCNCV 176_ CPGTV 181_ DTPSL 186_ QERIQ 191_ ARGNP 196_ EEARN 201_ DFLKR 206_ QKTGR 211_ FATAE 216_ EIAML 221_ CVYLA 226_ SDESA 231_ YVTGN 236_PVIID
1: NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity) (PubMed:35150746). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (PubMed:35150746). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372)