Respirasome Complex Assembly Factor 1 (Rab5-interacting protein) (RIP5)
1_MSGGR 6_ RKEEP 11_ PQPQL 16_ ANGAL 21_ KVSVW 26_ SKVLR 31_ SDAAW 36_ EDKDE 41_ FLDVI 46_ YWFRQ 51_ IIAVV 56_ LGVIW 61_ GVLPL 66_ RGFLG 71_ IAGFC 76_ LINAG 81_ VLYLY 86_ FSNYL 91_ QIDEE 96_ EYGGT 101_ WELTK 106_ EGFMT 111_ SFALF 116_ MVCVA 121_ DSFTT 126_ GHLDH 131_LLHCH
1: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (PubMed:36261522). In addition to its role in multi-pass membrane insertion, RAB5IF/OPTI also acts as an assembly factor for mitochondrial respiratory complexes (PubMed:31536960)