Glutathione-specific gamma-glutamylcyclotransferase 1 (Gamma-GCG 1) (EC 4.3.2.7) (Blocks Notch protein) (Botch) (Cation transport regulator-like protein 1)
1_MKQES 6_ AAPNT 11_ PPTSQ 16_ SPTPS 21_ AQFPR 26_ NDGDP 31_ QALWI 36_ FGYGS 41_ LVWRP 46_ DFAYS 51_ DSRVG 56_ FVRGY 61_ SRRFW 66_ QGDTF 71_ HRGSD 76_ KMPGR 81_ VVTLL 86_ EDHEG 91_ CTWGV 96_ AYQVQ 101_ GEQVS 106_ KALKY 111_ LNVRE 116_ AVLGG 121_ YDTKE 126_ VTFYP 131_ QDAPD 136_ QPLKA 141_ LAYVA 146_ TPQNP 151_ GYLGP 156_ APEEA 161_ IATQI 166_ LACRG 171_ FSGHN 176_ LEYLL 181_ RLADF 186_ MQLCG 191_ PQAQD 196_ EHLAA 201_ IVDAV 206_ GTMLP 211_ CFCPT 216_EQALA
1: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366)