TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)
1_MPGFD 6_ YKFLE 11_ KPKRR 16_ LLCPL 21_ CGKPM 26_ REPVQ 31_ VSTCG 36_ HRFCD 41_ TCLQE 46_ FLSEG 51_ VFKCP 56_ EDQLP 61_ LDYAK 66_ IYPDP 71_ ELEVQ 76_ VLGLP 81_ IRCIH 86_ SEEGC 91_ RWSGP 96_ LRHLQ 101_ GHLNT 106_ CSFNV 111_ IPCPN 116_ RCPMK 121_ LSRRD 126_ LPAHL 131_ QHDCP 136_ KRRLK 141_ CEFCG 146_ CDFSG 151_ EAYES 156_ HEGMC 161_ PQESV 166_ YCENK 171_ CGARM 176_ MRRLL 181_ AQHAT 186_ SECPK 191_ RTQPC 196_ TYCTK 201_ EFVFD 206_ TIQSH 211_ QYQCP 216_ RLPVA 221_ CPNQC 226_ GVGTV 231_ AREDL 236_ PGHLK 241_ DSCNT 246_ ALVLC 251_ PFKDS 256_ GCKHR 261_ CPKLA 266_ MARHV 271_ EESVK 276_ PHLAM 281_ MCALV 286_ SRQRQ 291_ ELQEL 296_ RRELE 301_ ELSVG 306_ SDGVL 311_ IWKIG 316_ SYGRR 321_ LQEAK 326_ AKPNL 331_ ECFSP 336_ AFYTH 341_ KYGYK 346_ LQVSA 351_ FLNGN 356_ GSGEG 361_ THLSL 366_ YIRVL 371_ PGAFD 376_ NLLEW 381_ PFARR 386_ VTFSL 391_ LDQSD 396_ PGLAK 401_ PQHVT 406_ ETFHP 411_ DPNWK 416_ NFQKP 421_ GTWRG 426_ SLDES 431_ SLGFG 436_ YPKFI 441_ SHQDI 446_ RKRNY 451_ VRDDA 456_ VFIRA 461_AVELP
1: Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed:31076633, PubMed:32268273, PubMed:33991522). Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed:30352854). Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed:31076633). Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed:32357935). In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed:33991522). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed:32268273)