Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12 homolog) (hALG12) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Mannosyltransferase ALG12 homolog) (Membrane protein SB87)
1_MAGKG 6_ SSGRR 11_ PLLLG 16_ LLVAV 21_ ATVHL 26_ VICPY 31_ TKVEE 36_ SFNLQ 41_ ATHDL 46_ LYHWQ 51_ DLEQY 56_ DHLEF 61_ PGVVP 66_ RTFLG 71_ PVVIA 76_ VFSSP 81_ AVYVL 86_ SLLEM 91_ SKFYS 96_ QLIVR 101_ GVLGL 106_ GVIFG 111_ LWTLQ 116_ KEVRR 121_ HFGAM 126_ VATMF 131_ CWVTA 136_ MQFHL 141_ MFYCT 146_ RTLPN 151_ VLALP 156_ VVLLA 161_ LAAWL 166_ RHEWA 171_ RFIWL 176_ SAFAI 181_ IVFRV 186_ ELCLF 191_ LGLLL 196_ LLALG 201_ NRKVS 206_ VVRAL 211_ RHAVP 216_ AGILC 221_ LGLTV 226_ AVDSY 231_ FWRQL 236_ TWPEG 241_ KVLWY 246_ NTVLN 251_ KSSNW 256_ GTSPL 261_ LWYFY 266_ SALPR 271_ GLGCS 276_ LLFIP 281_ LGLVD 286_ RRTHA 291_ PTVLA 296_ LGFMA 301_ LYSLL 306_ PHKEL 311_ RFIIY 316_ AFPML 321_ NITAA 326_ RGCSY 331_ LLNNY 336_ KKSWL 341_ YKAGS 346_ LLVIG 351_ HLVVN 356_ AAYSA 361_ TALYV 366_ SHFNY 371_ PGGVA 376_ MQRLH 381_ QLVPP 386_ QTDVL 391_ LHIDV 396_ AAAQT 401_ GVSRF 406_ LQVNS 411_ AWRYD 416_ KREDV 421_ QPGTG 426_ MLAYT 431_ HILME 436_ AAPGL 441_ LALYR 446_ DTHRV 451_ LASVV 456_ GTTGV 461_ SLNLT 466_ QLPPF 471_ NVHLQ 476_ TKLVL 481_LERLP
1: Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol