Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (Mediator of RhoA-dependent invasion) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein)
1_MTLEA 6_ IRYSR 11_ GSLQI 16_ LDQLL 21_ LPKQS 26_ RYEAV 31_ GSVHQ 36_ AWEAI 41_ RAMKV 46_ RGAPA 51_ IALVG 56_ CLSLA 61_ VELQA 66_ GAGGP 71_ GLAAL 76_ VAFVR 81_ DKLSF 86_ LVTAR 91_ PTAVN 96_ MARAA 101_ RDLAD 106_ VAARE 111_ AEREG 116_ ATEEA 121_ VRERV 126_ ICCTE 131_ DMLEK 136_ DLRDN 141_ RSIGD 146_ LGARH 151_ LLERV 156_ APSGG 161_ KVTVL 166_ THCNT 171_ GALAT 176_ AGYGT 181_ ALGVI 186_ RSLHS 191_ LGRLE 196_ HAFCT 201_ ETRPY 206_ NQGAR 211_ LTAFE 216_ LVYEQ 221_ IPATL 226_ ITDSM 231_ VAAAM 236_ AHRGV 241_ SAVVV 246_ GADRV 251_ VANGD 256_ TANKV 261_ GTYQL 266_ AIVAK 271_ HHGIP 276_ FYVAA 281_ PSSSC 286_ DLRLE 291_ TGKEI 296_ IIEER 301_ PGQEL 306_ TDVNG 311_ VRIAA 316_ PGIGV 321_ WNPAF 326_ DVTPH 331_ DLITG 336_ GIITE 341_ LGVFA 346_ PEELR 351_ TALTT 356_ TISSR 361_DGTLD
1: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover