Monoacylglycerol lipase ABHD6 (EC 3.1.1.23) (2-arachidonoylglycerol hydrolase) (Abhydrolase domain-containing protein 6)
1_MDLDV 6_ VNMFV 11_ IAGGT 16_ LAIPI 21_ LAFVA 26_ SFLLW 31_ PSALI 36_ RIYYW 41_ YWRRT 46_ LGMQV 51_ RYVHH 56_ EDYQF 61_ CYSFR 66_ GRPGH 71_ KPSIL 76_ MLHGF 81_ SAHKD 86_ MWLSV 91_ VKFLP 96_ KNLHL 101_ VCVDM 106_ PGHEG 111_ TTRSS 116_ LDDLS 121_ IDGQV 126_ KRIHQ 131_ FVECL 136_ KLNKK 141_ PFHLV 146_ GTSMG 151_ GQVAG 156_ VYAAY 161_ YPSDV 166_ SSLCL 171_ VCPAG 176_ LQYST 181_ DNQFV 186_ QRLKE 191_ LQGSA 196_ AVEKI 201_ PLIPS 206_ TPEEM 211_ SEMLQ 216_ LCSYV 221_ RFKVP 226_ QQILQ 231_ GLVDV 236_ RIPHN 241_ NFYRK 246_ LFLEI 251_ VSEKS 256_ RYSLH 261_ QNMDK 266_ IKVPT 271_ QIIWG 276_ KQDQV 281_ LDVSG 286_ ADMLA 291_ KSIAN 296_ CQVEL 301_ LENCG 306_ HSVVM 311_ ERPRK 316_ TAKLI 321_ IDFLA 326_ SVHNT 331_DNNKK
1: Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (By similarity). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015)