Calcium-binding mitochondrial carrier protein SCaMC-3 (Mitochondrial ATP-Mg/Pi carrier protein 2) (Mitochondrial Ca(2+)-dependent solute carrier protein 2) (Small calcium-binding mitochondrial carrier protein 3) (Solute carrier family 25 member 23)
1_MRGSP 6_ GDAER 11_ RQRWG 16_ RLFEE 21_ LDSNK 26_ DGRVD 31_ VHELR 36_ QGLAR 41_ LGGGN 46_ PDPGA 51_ QQGIS 56_ SEGDA 61_ DPDGG 66_ LDLEE 71_ FSRYL 76_ QEREQ 81_ RLLLM 86_ FHSLD 91_ RNQDG 96_ HIDVS 101_ EIQQS 106_ FRALG 111_ ISISL 116_ EQAEK 121_ ILHSM 126_ DRDGT 131_ MTIDW 136_ QEWRD 141_ HFLLH 146_ SLENV 151_ EDVLY 156_ FWKHS 161_ TVLDI 166_ GECLT 171_ VPDEF 176_ SKQEK 181_ LTGMW 186_ WKQLV 191_ AGAVA 196_ GAVSR 201_ TGTAP 206_ LDRLK 211_ VFMQV 216_ HASKT 221_ NRLNI 226_ LGGLR 231_ SMVLE 236_ GGIRS 241_ LWRGN 246_ GINVL 251_ KIAPE 256_ SAIKF 261_ MAYEQ 266_ IKRAI 271_ LGQQE 276_ TLHVQ 281_ ERFVA 286_ GSLAG 291_ ATAQT 296_ IIYPM 301_ EVLKT 306_ RLTLR 311_ RTGQY 316_ KGLLD 321_ CARRI 326_ LEREG 331_ PRAFY 336_ RGYLP 341_ NVLGI 346_ IPYAG 351_ IDLAV 356_ YETLK 361_ NWWLQ 366_ QYSHD 371_ SADPG 376_ ILVLL 381_ ACGTI 386_ SSTCG 391_ QIASY 396_ PLALV 401_ RTRMQ 406_ AQASI 411_ EGGPQ 416_ LSMLG 421_ LLRHI 426_ LSQEG 431_ MRGLY 436_ RGIAP 441_ NFMKV 446_ IPAVS 451_ ISYVV 456_ YENMK 461_QALGV
1: Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways (PubMed:15123600). Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP (PubMed:24430870, PubMed:28695448). In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides (PubMed:15123600)