WD repeat-containing protein 18
1_MAAPM 6_ EVAVC 11_ TDSAA 16_ PMWSC 21_ IVWEL 26_ HSGAN 31_ LLTYR 36_ GGQAG 41_ PRGLA 46_ LLNGE 51_ YLLAA 56_ QLGKN 61_ YISAW 66_ ELQRK 71_ DQLQQ 76_ KIMCP 81_ GPVTC 86_ LTASP 91_ NGLYV 96_ LAGVA 101_ ESIHL 106_ WEVST 111_ GNLLV 116_ ILSRH 121_ YQDVS 126_ CLQFT 131_ GDSSH 136_ FISGG 141_ KDCLV 146_ LVWSL 151_ CSVLQ 156_ ADPSR 161_ IPAPR 166_ HVWSH 171_ HALPI 176_ TDLHC 181_ GFGGP 186_ LARVA 191_ TSSLD 196_ QTVKL 201_ WEVSS 206_ GELLL 211_ SVLFD 216_ VSIMA 221_ VTMDL 226_ AEHHM 231_ FCGGS 236_ EGSIF 241_ QVDLF 246_ TWPGQ 251_ RERSF 256_ HPEQD 261_ AGKVF 266_ KGHRN 271_ QVTCL 276_ SVSTD 281_ GSVLL 286_ SGSHD 291_ ETVRL 296_ WDVQS 301_ KQCIR 306_ TVALK 311_ GPVTN 316_ AAILL 321_ APVSM 326_ LSSDF 331_ RPSLP 336_ LPHFN 341_ KHLLG 346_ AEHGD 351_ EPRHG 356_ GLTLR 361_ LGLHQ 366_ QGSEP 371_ SYLDR 376_ TEQLQ 381_ AVLCS 386_ TMEKS 391_ VLGGQ 396_ DQLRV 401_ RVTEL 406_ EDEVR 411_ NLRKI 416_ NRDLF 421_ DFSTR 426_FITRP
1: Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). May play a role during development (By similarity)