Vesicle-associated membrane protein 8 (VAMP-8) (Endobrevin) (EDB)
1_MEEAS 6_ EGGGN 11_ DRVRN 16_ LQSEV 21_ EGVKN 26_ IMTQN 31_ VERIL 36_ ARGEN 41_ LEHLR 46_ NKTED 51_ LEATS 56_ EHFKT 61_ TSQKV 66_ ARKFW 71_ WKNVK 76_ MIVLI 81_ CVIVF 86_ IIILF 91_IVLFA
1: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Also plays a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity). Also participates in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (PubMed:31694946)