tRNA (guanine(6)-N2)-methyltransferase THUMP3 (EC 2.1.1.256) (THUMP domain-containing protein 3)
1_MCDIE 6_ EATNQ 11_ LLDVN 16_ LHENQ 21_ KSVQV 26_ TESDL 31_ GSESE 36_ LLVTI 41_ GATVP 46_ TGFEQ 51_ TAADE 56_ VREKL 61_ GSSCK 66_ ISRDR 71_ GKIYF 76_ VISVE 81_ SLAQV 86_ HCLRS 91_ VDNLF 96_ VVVQE 101_ FQDYQ 106_ FKQTK 111_ EEVLK 116_ DFEDL 121_ AGKLP 126_ WSNPL 131_ KVWKI 136_ NASFK 141_ KKKAK 146_ RKKIN 151_ QNSSK 156_ EKINN 161_ GQEVK 166_ IDQRN 171_ VKKEF 176_ TSHAL 181_ DSHIL 186_ DYYEN 191_ PAIKE 196_ DVSTL 201_ IGDDL 206_ ASCKD 211_ ETDES 216_ SKEET 221_ EPQVL 226_ KFRVT 231_ CNRAG 236_ EKHCF 241_ TSNEA 246_ ARDFG 251_ GAVQD 256_ YFKWK 261_ ADMTN 266_ FDVEV 271_ LLNIH 276_ DNEVI 281_ VGIAL 286_ TEESL 291_ HRRNI 296_ THFGP 301_ TTLRS 306_ TLAYG 311_ MLRLC 316_ DPLPY 321_ DIIVD 326_ PMCGT 331_ GAIPI 336_ EGATE 341_ WSDCF 346_ HIAGD 351_ NNPLA 356_ VNRAA 361_ NNIAS 366_ LLTKS 371_ QIKEG 376_ KPSWG 381_ LPIDA 386_ VQWDI 391_ CNLPL 396_ RTGSV 401_ DIIVT 406_ DLPFG 411_ KRMGS 416_ KKRNW 421_ NLYPA 426_ CLREM 431_ SRVCT 436_ PTTGR 441_ AVLLT 446_ QDTKC 451_ FTKAL 456_ SGMRH 461_ VWRKV 466_ DTVWV 471_ NVGGL 476_ RAAVY 481_ VLIRT 486_ PQAFV 491_ HPSEQ 496_ DGERG 501_TLWQC
1: Catalytic subunit of the THUMPD3-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 6 (m2G6) in tRNAs (PubMed:34669960, PubMed:37283053). This is one of the major tRNA (guanine-N(2))-methyltransferases (PubMed:37283053). Also catalyzes the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 7 of tRNA(Trp) (PubMed:34669960)