Dual specificity protein phosphatase 26 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase SKRP3) (Low-molecular-mass dual-specificity phosphatase 4) (DSP-4) (LDP-4) (Mitogen-activated protein kinase phosphatase 8) (MAP kinase phosphatase 8) (MKP-8) (Novel amplified gene in thyroid anaplastic cancer)
1_MCPGN 6_ WLWAS 11_ MTFMA 16_ RFSRS 21_ SSRSP 26_ VRTRG 31_ TLEEM 36_ PTVQH 41_ PFLNV 46_ FELER 51_ LLYTG 56_ KTACN 61_ HADEV 66_ WPGLY 71_ LGDQD 76_ MANNR 81_ RELRR 86_ LGITH 91_ VLNAS 96_ HSRWR 101_ GTPEA 106_ YEGLG 111_ IRYLG 116_ VEAHD 121_ SPAFD 126_ MSIHF 131_ QTAAD 136_ FIHRA 141_ LSQPG 146_ GKILV 151_ HCAVG 156_ VSRSA 161_ TLVLA 166_ YLMLY 171_ HHLTL 176_ VEAIK 181_ KVKDH 186_ RGIIP 191_ NRGFL 196_ RQLLA 201_ LDRRL 206_RQGLE
1: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK)