E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126)
1_MAEAS 6_ PHPGR 11_ YFCHC 16_ CSVEI 21_ VPRLP 26_ DYICP 31_ RCESG 36_ FIEEL 41_ PEETR 46_ STENG 51_ SAPST 56_ APTDQ 61_ SRPPL 66_ EHVDQ 71_ HLFTL 76_ PQGYG 81_ QFAFG 86_ IFDDS 91_ FEIPT 96_ FPPGA 101_ QADDG 106_ RDPES 111_ RRERD 116_ HPSRH 121_ RYGAR 126_ QPRAR 131_ LTTRR 136_ ATGRH 141_ EGVPT 146_ LEGII 151_ QQLVN 156_ GIITP 161_ ATIPS 166_ LGPWG 171_ VLHSN 176_ PMDYA 181_ WGANG 186_ LDAII 191_ TQLLN 196_ QFENT 201_ GPPPA 206_ DKEKI 211_ QALPT 216_ VPVTE 221_ EHVGS 226_ GLECP 231_ VCKDD 236_ YALGE 241_ RVRQL 246_ PCNHL 251_ FHDGC 256_ IVPWL 261_ EQHDS 266_ CPVCR 271_ KSLTG 276_ QNTAT 281_ NPPGL 286_ TGVSF 291_ SSSSS 296_ SSSSS 301_ SPSNE 306_NATSN
1: E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174, PubMed:36563124). Depending on the associated E2 ligase, mediates 'Lys-27'-, 'Lys-29'-, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates (PubMed:36563124). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174, PubMed:29042515). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564). Acts as a regulator of DNA repair by mediating 'Lys-27'- and 'Lys-29'-linked polyubiquitination of MRE11, thereby promoting the exonuclease activity of MRE11 (PubMed:36563124)