N-terminal Xaa-Pro-Lys N-methyltransferase 1 (EC 2.1.1.244) (Alpha N-terminal protein methyltransferase 1A) (Methyltransferase-like protein 11A) (N-terminal RCC1 methyltransferase) (X-Pro-Lys N-terminal protein methyltransferase 1A) (NTM1A) [Cleaved into: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed]
1_MTSEV 6_ IEDEK 11_ QFYSK 16_ AKTYW 21_ KQIPP 26_ TVDGM 31_ LGGYG 36_ HISSI 41_ DINSS 46_ RKFLQ 51_ RFLRE 56_ GPNKT 61_ GTSCA 66_ LDCGA 71_ GIGRI 76_ TKRLL 81_ LPLFR 86_ EVDMV 91_ DITED 96_ FLVQA 101_ KTYLG 106_ EEGKR 111_ VRNYF 116_ CCGLQ 121_ DFTPE 126_ PDSYD 131_ VIWIQ 136_ WVIGH 141_ LTDQH 146_ LAEFL 151_ RRCKG 156_ SLRPN 161_ GIIVI 166_ KDNMA 171_ QEGVI 176_ LDDVD 181_ SSVCR 186_ DLDVV 191_ RRIIC 196_ SAGLS 201_ LLAEE 206_ RQENL 211_ PDEIY 216_HVYSF
1: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1