ER degradation-enhancing alpha-mannosidase-like protein 2
1_MPFRL 6_ LIPLG 11_ LLCAL 16_ LPQHH 21_ GAPGP 26_ DGSAP 31_ DPAHY 36_ RERVK 41_ AMFYH 46_ AYDSY 51_ LENAF 56_ PFDEL 61_ RPLTC 66_ DGHDT 71_ WGSFS 76_ LTLID 81_ ALDTL 86_ LILGN 91_ VSEFQ 96_ RVVEV 101_ LQDSV 106_ DFDID 111_ VNASV 116_ FETNI 121_ RVVGG 126_ LLSAH 131_ LLSKK 136_ AGVEV 141_ EAGWP 146_ CSGPL 151_ LRMAE 156_ EAARK 161_ LLPAF 166_ QTPTG 171_ MPYGT 176_ VNLLH 181_ GVNPG 186_ ETPVT 191_ CTAGI 196_ GTFIV 201_ EFATL 206_ SSLTG 211_ DPVFE 216_ DVARV 221_ ALMRL 226_ WESRS 231_ DIGLV 236_ GNHID 241_ VLTGK 246_ WVAQD 251_ AGIGA 256_ GVDSY 261_ FEYLV 266_ KGAIL 271_ LQDKK 276_ LMAMF 281_ LEYNK 286_ AIRNY 291_ TRFDD 296_ WYLWV 301_ QMYKG 306_ TVSMP 311_ VFQSL 316_ EAYWP 321_ GLQSL 326_ IGDID 331_ NAMRT 336_ FLNYY 341_ TVWKQ 346_ FGGLP 351_ EFYNI 356_ PQGYT 361_ VEKRE 366_ GYPLR 371_ PELIE 376_ SAMYL 381_ YRATG 386_ DPTLL 391_ ELGRD 396_ AVESI 401_ EKISK 406_ VECGF 411_ ATIKD 416_ LRDHK 421_ LDNRM 426_ ESFFL 431_ AETVK 436_ YLYLL 441_ FDPTN 446_ FIHNN 451_ GSTFD 456_ AVITP 461_ YGECI 466_ LGAGG 471_ YIFNT 476_ EAHPI 481_ DPAAL 486_ HCCQR 491_ LKEEQ 496_ WEVED 501_ LMREF 506_ YSLKR 511_ SRSKF 516_ QKNTV 521_ SSGPW 526_ EPPAR 531_ PGTLF 536_ SPENH 541_ DQARE 546_ RKPAK 551_ QKVPL 556_ LSCPS 561_ QPFTS 566_ KLALL 571_GQVFL
1: Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity)