Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (EC 2.4.99.-) (GD1 alpha synthase) (GalNAc alpha-2,6-sialyltransferase V) (ST6GalNAc V) (ST6GalNAcV) (Sialyltransferase 7E) (SIAT7-E)
1_MKTLM 6_ RHGLA 11_ VCLAL 16_ TTMCT 21_ SLLLV 26_ YSSLG 31_ GQKER 36_ PPQQQ 41_ QQQQQ 46_ QQQQA 51_ SATGS 56_ SQPAA 61_ ESSTQ 66_ QRPGV 71_ PAGPR 76_ PLDGY 81_ LGVAD 86_ HKPLK 91_ MHCRD 96_ CALVT 101_ SSGHL 106_ LHSRQ 111_ GSQID 116_ QTECV 121_ IRMND 126_ APTRG 131_ YGRDV 136_ GNRTS 141_ LRVIA 146_ HSSIQ 151_ RILRN 156_ RHDLL 161_ NVSQG 166_ TVFIF 171_ WGPSS 176_ YMRRD 181_ GKGQV 186_ YNNLH 191_ LLSQV 196_ LPRLK 201_ AFMIT 206_ RHKML 211_ QFDEL 216_ FKQET 221_ GKDRK 226_ ISNTW 231_ LSTGW 236_ FTMTI 241_ ALELC 246_ DRINV 251_ YGMVP 256_ PDFCR 261_ DPNHP 266_ SVPYH 271_ YYEPF 276_ GPDEC 281_ TMYLS 286_ HERGR 291_ KGSHH 296_ RFITE 301_ KRVFK 306_ NWART 311_ FNIHF 316_ FQPDW 321_ KPESL 326_ AINHP 331_ENKPV
1: Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675)