Dual specificity protein phosphatase 23 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z)
1_MGVQP 6_ PNFSW 11_ VLPGR 16_ LAGLA 21_ LPRLP 26_ AHYQF 31_ LLDLG 36_ VRHLV 41_ SLTER 46_ GPPHS 51_ DSCPG 56_ LTLHR 61_ LRIPD 66_ FCPPA 71_ PDQID 76_ RFVQI 81_ VDEAN 86_ ARGEA 91_ VGVHC 96_ ALGFG 101_ RTGTM 106_ LACYL 111_ VKERG 116_ LAAGD 121_ AIAEI 126_ RRLRP 131_ GSIET 136_ YEQEK 141_AVFQF
1: Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14)