Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.265) (Asparagine-linked glycosylation protein 8 homolog) (Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase)
1_MAALT 6_ IATGT 11_ GNWFS 16_ ALALG 21_ VTLLK 26_ CLLIP 31_ TYHST 36_ DFEVH 41_ RNWLA 46_ ITHSL 51_ PISQW 56_ YYEAT 61_ SEWTL 66_ DYPPF 71_ FAWFE 76_ YILSH 81_ VAKYF 86_ DQEML 91_ NVHNL 96_ NYSSS 101_ RTLLF 106_ QRFSV 111_ IFMDV 116_ LFVYA 121_ VRECC 126_ KCIDG 131_ KKVGK 136_ ELTEK 141_ PKFIL 146_ SVLLL 151_ WNFGL 156_ LIVDH 161_ IHFQY 166_ NGFLF 171_ GLMLL 176_ SIARL 181_ FQKRH 186_ MEGAF 191_ LFAVL 196_ LHFKH 201_ IYLYV 206_ APAYG 211_ VYLLR 216_ SYCFT 221_ ANKPD 226_ GSIRW 231_ KSFSF 236_ VRVIS 241_ LGLVV 246_ FLVSA 251_ LSLGP 256_ FLALN 261_ QLPQV 266_ FSRLF 271_ PFKRG 276_ LCHAY 281_ WAPNF 286_ WALYN 291_ ALDKV 296_ LSVIG 301_ LKLKF 306_ LDPNN 311_ IPKAS 316_ MTSGL 321_ VQQFQ 326_ HTVLP 331_ SVTPL 336_ ATLIC 341_ TLIAI 346_ LPSIF 351_ CLWFK 356_ PQGPR 361_ GFLRC 366_ LTLCA 371_ LSSFM 376_ FGWHV 381_ HEKAI 386_ LLAIL 391_ PMSLL 396_ SVGKA 401_ GDASI 406_ FLILT 411_ TTGHY 416_ SLFPL 421_ LFTAP 426_ ELPIK 431_ ILLML 436_ LFTIY 441_ SISSL 446_ KTLFR 451_ KEKPL 456_ FNWME 461_ TFYLL 466_ GLGPL 471_ EVCCE 476_ FVFPF 481_ TSWKV 486_ KYPFI 491_ PLLLT 496_ SVYCA 501_ VGITY 506_ AWFKL 511_ YVSVL 516_ IDSAI 521_GKTKK
1: Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol. Glc(2)Man(9)GlcNAc(2)-PP-Dol is a substrate for ALG10, the following enzyme in the biosynthetic pathway (PubMed:12480927, PubMed:15235028). Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia (By similarity)