Transmembrane emp24 domain-containing protein 9 (GMP25) (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2) (p25)
1_MAVEL 6_ GVLLV 11_ RPRPG 16_ TGLGR 21_ VMRTL 26_ LLVLW 31_ LATRG 36_ SALYF 41_ HIGET 46_ EKKCF 51_ IEEIP 56_ DETMV 61_ IGNYR 66_ TQLYD 71_ KQREE 76_ YQPAT 81_ PGLGM 86_ FVEVK 91_ DPEDK 96_ VILAR 101_ QYGSE 106_ GRFTF 111_ TSHTP 116_ GEHQI 121_ CLHSN 126_ STKFS 131_ LFAGG 136_ MLRVH 141_ LDIQV 146_ GEHAN 151_ DYAEI 156_ AAKDK 161_ LSELQ 166_ LRVRQ 171_ LVEQV 176_ EQIQK 181_ EQNYQ 186_ RWREE 191_ RFRQT 196_ SESTN 201_ QRVLW 206_ WSILQ 211_ TLILV 216_ AIGVW 221_ QMRHL 226_KSFFE
1: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB