Transmembrane protein 147 (Protein NIFIE 14)
1_MTLFH 6_ FGNCF 11_ ALAYF 16_ PYFIT 21_ YKCSG 26_ LSEYN 31_ AFWKC 36_ VQAGV 41_ TYLFV 46_ QLCKM 51_ LFLAT 56_ FFPTW 61_ EGGIY 66_ DFIGE 71_ FMKAS 76_ VDVAD 81_ LIGLN 86_ LVMSR 91_ NAGKG 96_ EYKIM 101_ VAALG 106_ WATAE 111_ LIMSR 116_ CIPLW 121_ VGARG 126_ IEFDW 131_ KYIQM 136_ SIDSN 141_ ISLVH 146_ YIVAS 151_ AQVWM 156_ ITRYD 161_ LYHTF 166_ RPAVL 171_ LLMFL 176_ SVYKA 181_ FVMET 186_ FVHLC 191_ SLGSW 196_ AALLA 201_ RAVVT 206_ GLLAL 211_ STLAL 216_YVAVV
1: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (PubMed:21056967). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (PubMed:21056967). Regulates LBR localization to the nucleus inner membrane (PubMed:32694168)