Spermatogenesis-associated protein 5-like protein 1
1_MAPDS 6_ DPFPE 11_ GPLLK 16_ LLPLD 21_ ARDRG 26_ TQRCR 31_ LGPAA 36_ LHALG 41_ ARLGS 46_ AVKIS 51_ LPDGG 56_ SCLCT 61_ AWPRR 66_ DGADG 71_ FVQLD 76_ PLCAS 81_ PGAAV 86_ GASRS 91_ RRSLS 96_ LNRLL 101_ LVPCP 106_ PLRRV 111_ AVWPV 116_ LRERA 121_ GAPGA 126_ RNTAA 131_ VLEAA 136_ QELLR 141_ NRPIS 146_ LGHVV 151_ VAPPG 156_ APGLV 161_ AALHI 166_ VGGTP 171_ SPDPA 176_ GLVTP 181_ RTRVS 186_ LGGEP 191_ PSEAQ 196_ PQPEV 201_ PLGGL 206_ SEAAD 211_ SLREL 216_ LRLPL 221_ RYPRA 226_ LTALG 231_ LAVPR 236_ GVLLA 241_ GPPGV 246_ GKTQL 251_ VRAVA 256_ REAGA 261_ ELLAV 266_ SAPAL 271_ QGSRP 276_ GETEE 281_ NVRRV 286_ FQRAR 291_ ELASR 296_ GPSLL 301_ FLDEM 306_ DALCP 311_ QRGSR 316_ APESR 321_ VVAQV 326_ LTLLD 331_ GASGD 336_ REVVV 341_ VGATN 346_ RPDAL 351_ DPALR 356_ RPGRF 361_ DREVV 366_ IGTPT 371_ LKQRK 376_ EILQV 381_ ITSKM 386_ PISSH 391_ VDLGL 396_ LAEMT 401_ VGYVG 406_ ADLTA 411_ LCREA 416_ AMHAL 421_ LHSEK 426_ NQDNP 431_ VIDEI 436_ DFLEA 441_ FKNIQ 446_ PSSFR 451_ SVIGL 456_ MDIKP 461_ VDWEE 466_ IGGLE 471_ DVKLK 476_ LKQSI 481_ EWPLK 486_ FPWEF 491_ VRMGL 496_ TQPKG 501_ VLLYG 506_ PPGCA 511_ KTTLV 516_ RALAT 521_ SCHCS 526_ FVSVS 531_ GADLF 536_ SPFVG 541_ DSEKV 546_ LSQIF 551_ RQARA 556_ STPAI 561_ LFLDE 566_ IDSIL 571_ GARSA 576_ SKTGC 581_ DVQER 586_ VLSVL 591_ LNELD 596_ GVGLK 601_ TIERR 606_ GSKSS 611_ QQEFQ 616_ EVFNR 621_ SVMII 626_ AATNR 631_ PDVLD 636_ TALLR 641_ PGRLD 646_ KIIYI 651_ PPPDH 656_ KGRLS 661_ ILKVC 666_ TKTMP 671_ IGPDV 676_ SLENL 681_ AAETC 686_ FFSGA 691_ DLRNL 696_ CTEAA 701_ LLALQ 706_ ENGLD 711_ ATTVK 716_ QEHFL 721_ KSLKT 726_ VKPSL 731_ SCKDL 736_ ALYEN 741_ LFKKE 746_GFSNV
1: ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024)