tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-)
1_MLMAW 6_ CRGPV 11_ LLCLR 16_ QGLGT 21_ NSFLH 26_ GLGQE 31_ PFEGA 36_ RSLCC 41_ RSSPR 46_ DLRDG 51_ EREHE 56_ AAQRK 61_ APGAE 66_ SCPSL 71_ PLSIS 76_ DIGTG 81_ CLSSL 86_ ENLRL 91_ PTLRE 96_ ESSPR 101_ ELEDS 106_ SGDQG 111_ RCGPT 116_ HQGSE 121_ DPSML 126_ SQAQS 131_ ATEVE 136_ ERHVS 141_ PSCST 146_ SRERP 151_ FQAGE 156_ LILAE 161_ TGEGE 166_ TKFKK 171_ LFRLN 176_ NFGLL 181_ NSNWG 186_ AVPFG 191_ KIVGK 196_ FPGQI 201_ LRSSF 206_ GKQYM 211_ LRRPA 216_ LEDYV 221_ VLMKR 226_ GTAIT 231_ FPKDI 236_ NMILS 241_ MMDIN 246_ PGDTV 251_ LEAGS 256_ GSGGM 261_ SLFLS 266_ KAVGS 271_ QGRVI 276_ SFEVR 281_ KDHHD 286_ LAKKN 291_ YKHWR 296_ DSWKL 301_ SHVEE 306_ WPDNV 311_ DFIHK 316_ DISGA 321_ TEDIK 326_ SLTFD 331_ AVALD 336_ MLNPH 341_ VTLPV 346_ FYPHL 351_ KHGGV 356_ CAVYV 361_ VNITQ 366_ VIELL 371_ DGIRT 376_ CELAL 381_ SCEKI 386_ SEVIV 391_ RDWLV 396_ CLAKQ 401_ KNGIL 406_ AQKVE 411_ SKINT 416_ DVQLD 421_ SQEKI 426_ GVKGE 431_ LFQED 436_ DHEES 441_ HSDFP 446_ YGSFP 451_ YVARP 456_ VHWQP 461_ GHTAF 466_ LVKLR 471_KVKPQ
1: Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537)