Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS]
1_MTLIE 6_ GVGDE 11_ VTVLF 16_ SVLAC 21_ LLVLA 26_ LAWVS 31_ THTAE 36_ GGDPL 41_ PQPSG 46_ TPTPS 51_ QPSAA 56_ MAATD 61_ SMRGE 66_ APGAE 71_ TPSLR 76_ HRGQA 81_ AQPEP 86_ STGFT 91_ ATPPA 96_ PDSPQ 101_ EPLVL 106_ RLKFL 111_ NDSEQ 116_ VARAW 121_ PHDTI 126_ GSLKR 131_ TQFPG 136_ REQQV 141_ RLIYQ 146_ GQLLG 151_ DDTQT 156_ LGSLH 161_ LPPNC 166_ VLHCH 171_ VSTRV 176_ GPPNP 181_ PCPPG 186_ SEPGP 191_ SGLEI 196_ GSLLL 201_ PLLLL 206_ LLLLL 211_ WYCQI 216_ QYRPF 221_ FPLTA 226_ TLGLA 231_ GFTLL 236_ LSLLA 241_FAMYR
1: Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity)
2: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity)