TIMELESS-interacting protein
1_MLEPQ 6_ ENGVI 11_ DLPDY 16_ EHVED 21_ ETFPP 26_ FPPPA 31_ SPERQ 36_ DGEGT 41_ EPDEE 46_ SGNGA 51_ PVRVP 56_ PKRTV 61_ KRNIP 66_ KLDAQ 71_ RLISE 76_ RGLPA 81_ LRHVF 86_ DKAKF 91_ KGKGH 96_ EAEDL 101_ KMLIR 106_ HMEHW 111_ AHRLF 116_ PKLQF 121_ EDFID 126_ RVEYL 131_ GSKKE 136_ VQTCL 141_ KRIRL 146_ DLPIL 151_ HEDFV 156_ SNNDE 161_ VAENN 166_ EHDVT 171_ STELD 176_ PFLTN 181_ LSESE 186_ MFASE 191_ LSRSL 196_ TEEQQ 201_ QRIER 206_ NKQLA 211_ LERRQ 216_ AKLLS 221_ NSQTL 226_ GNDML 231_ MNTPR 236_ AHTVE 241_ EVNTD 246_ EDQKE 251_ ESNGL 256_ NEDIL 261_ DNPCN 266_ DAIAN 271_ TLNEE 276_ ETLLD 281_ QSFKN 286_ VQQQL 291_ DATSR 296_NITEA
1: Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:17102137, PubMed:23359676, PubMed:35585232). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17102137, PubMed:17116885, PubMed:17296725, PubMed:23359676, PubMed:35585232)