Elongation of very long chain fatty acids protein 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Very long chain 3-ketoacyl-CoA synthase 1) (Very long chain 3-oxoacyl-CoA synthase 1)
1_MEAVV 6_ NLYQE 11_ VMKHA 16_ DPRIQ 21_ GYPLM 26_ GSPLL 31_ MTSIL 36_ LTYVY 41_ FVLSL 46_ GPRIM 51_ ANRKP 56_ FQLRG 61_ FMIVY 66_ NFSLV 71_ ALSLY 76_ IVYEF 81_ LMSGW 86_ LSTYT 91_ WRCDP 96_ VDYSN 101_ SPEAL 106_ RMVRV 111_ AWLFL 116_ FSKFI 121_ ELMDT 126_ VIFIL 131_ RKKDG 136_ QVTFL 141_ HVFHH 146_ SVLPW 151_ SWWWG 156_ VKIAP 161_ GGMGS 166_ FHAMI 171_ NSSVH 176_ VIMYL 181_ YYGLS 186_ AFGPV 191_ AQPYL 196_ WWKKH 201_ MTAIQ 206_ LIQFV 211_ LVSLH 216_ ISQYY 221_ FMSSC 226_ NYQYP 231_ VIIHL 236_ IWMYG 241_ TIFFM 246_ LFSNF 251_ WYHSY 256_ TKGKR 261_ LPRAL 266_ QQNGA 271_PGIAK
1: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed:29496980, PubMed:30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis (PubMed:20937905). Indirectly inhibits RPE65 via production of VLCFAs