Cyclin-dependent kinase 2-interacting protein (CDK2-interacting protein)
1_MEAKT 6_ LGTVT 11_ PRKPV 16_ LSVSA 21_ RKIKD 26_ NAADW 31_ HNLIL 36_ KWETL 41_ NDAGF 46_ TTANN 51_ IANLK 56_ ISLLN 61_ KDKIE 66_ LDSSS 71_ PASKE 76_ NEEKV 81_ CLEYN 86_ EELEK 91_ LCEEL 96_ QATLD 101_ GLTKI 106_ QVKME 111_ KLSST 116_ TKGIC 121_ ELENY 126_ HYGEE 131_ SKRPP 136_ LFHTW 141_ PTTHF 146_ YEVSH 151_ KLLEM 156_ YRKEL 161_ LLKRT 166_ VAKEL 171_ AHTGD 176_ PDLTL 181_ SYLSM 186_ WLHQP 191_ YVESD 196_ SRLHL 201_ ESMLL 206_ETGHR
1: Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication (PubMed:16082200, PubMed:19889979). Regulates ATR-mediated checkpoint signaling in response to DNA damage (PubMed:16082200, PubMed:19889979). Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). As part of 55LCC complex, also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024)