Intraflagellar transport protein 27 homolog (Putative GTP-binding protein RAY-like) (Rab-like protein 4)
1_MVKLA 6_ AKCIL 11_ AGDPA 16_ VGKTA 21_ LAQIF 26_ RSDGA 31_ HFQKS 36_ YTLTT 41_ GMDLV 46_ VKTVP 51_ VPDTG 56_ DSVEL 61_ FIFDS 66_ AGKEL 71_ FSEML 76_ DKLWE 81_ SPNVL 86_ CLVYD 91_ VTNEE 96_ SFNNC 101_ SKWLE 106_ KARSQ 111_ APGIS 116_ LPGVL 121_ VGNKT 126_ DLAGR 131_ RAVDS 136_ AEARA 141_ WALGQ 146_ GLECF 151_ ETSVK 156_ EMENF 161_ EAPFH 166_ CLAKQ 171_ FHQLY 176_ REKVE 181_VFRAL
1: Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity)