Splicing factor YJU2 (Coiled-coil domain-containing protein 94)
1_MSERK 6_ VLNKY 11_ YPPDF 16_ DPSKI 21_ PKLKL 26_ PKDRQ 31_ YVVRL 36_ MAPFN 41_ MRCKT 46_ CGEYI 51_ YKGKK 56_ FNARK 61_ ETVQN 66_ EVYLG 71_ LPIFR 76_ FYIKC 81_ TRCLA 86_ EITFK 91_ TDPEN 96_ TDYTM 101_ EHGAT 106_ RNFQA 111_ EKLLE 116_ EEEKR 121_ VQKER 126_ EDEEL 131_ NNPMK 136_ VLENR 141_ TKDSK 146_ LEMEV 151_ LENLQ 156_ ELKDL 161_ NQRQA 166_ HVDFE 171_ AMLRQ 176_ HRLSE 181_ EERRR 186_ QQQEE 191_ DEQET 196_ AALLE 201_ EARKR 206_ RLLED 211_ SDSED 216_ EAAPS 221_ PLQPA 226_ LRPNP 231_ TAILD 236_ EAPKP 241_ KRKVE 246_ VWEQS 251_ VGSLG 256_ SRPPL 261_ SRLVV 266_ VKKAK 271_ ADPDC 276_ SNGQP 281_ QAAPT 286_ PGAPQ 291_ NRKEA 296_ NPTPL 301_ TPGAS 306_ SLSQL 311_ GAYLD 316_SDDSN
1: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:29301961). Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453)