E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein)
1_MPIRA 6_ LCTIC 11_ SDFFD 16_ HSRDV 21_ AAIHC 26_ GHTFH 31_ LQCLI 36_ QWFET 41_ APSRT 46_ CPQCR 51_ IQVGK 56_ RTIIN 61_ KLFFD 66_ LAQEE 71_ ENVLD 76_ AEFLK 81_ NELDN 86_ VRAQL 91_ SQKDK 96_ EKRDS 101_ QVIID 106_ TLRDT 111_ LEERN 116_ ATVVS 121_ LQQAL 126_ GKAEM 131_ LCSTL 136_ KKQMK 141_ YLEQQ 146_ QDETK 151_ QAQEE 156_ ARRLR 161_ SKMKT 166_ MEQIE 171_ LLLQS 176_ QRPEV 181_ EEMIR 186_ DMGVG 191_ QSAVE 196_ QLAVY 201_ CVSLK 206_ KEYEN 211_ LKEAR 216_ KASGE 221_ VADKL 226_ RKDLF 231_ SSRSK 236_ LQTVY 241_ SELDQ 246_ AKLEL 251_ KSAQK 256_ DLQSA 261_ DKEIM 266_ SLKKK 271_ LTMLQ 276_ ETLNL 281_ PPVAS 286_ ETVDR 291_ LVLES 296_ PAPVE 301_ VNLKL 306_ RRPSF 311_ RDDID 316_ LNATF 321_ DVDTP 326_ PARPS 331_ SSQHG 336_ YYEKL 341_ CLEKS 346_ HSPIQ 351_ DVPKK 356_ ICKGP 361_ RKESQ 366_ LSLGG 371_ QSCAG 376_ EPDEE 381_ LVGAF 386_ PIFVR 391_ NAILG 396_ QKQPK 401_ RPRSE 406_ SSCSK 411_ DVVRT 416_ GFDGL 421_ GGRTK 426_ FIQPT 431_ DTVMI 436_ RPLPV 441_ KPKTK 446_ VKQRV 451_ RVKTV 456_ PSLFQ 461_AKLDT
1: E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:25335891, PubMed:26595769, PubMed:26711499, PubMed:26781088, PubMed:27462463, PubMed:31545170). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is however controversial (PubMed:26595769). Acts as a regulator of the spindle assembly checkpoint (PubMed:25335891). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920)