RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a)
1_MVKLF 6_ IGNLP 11_ REATE 16_ QEIRS 21_ LFEQY 26_ GKVLE 31_ CDIIK 36_ NYGFV 41_ HIEDK 46_ TAAED 51_ AIRNL 56_ HHYKL 61_ HGVNI 66_ NVEAS 71_ KNKSK 76_ TSTKL 81_ HVGNI 86_ SPTCT 91_ NKELR 96_ AKFEE 101_ YGPVI 106_ ECDIV 111_ KDYAF 116_ VHMER 121_ AEDAV 126_ EAIRG 131_ LDNTE 136_ FQGKR 141_ MHVQL 146_ STSRL 151_ RTAPG 156_ MGDQS 161_ GCYRC 166_ GKEGH 171_ WSKEC 176_ PIDRS 181_ GRVAD 186_ LTEQY 191_ NEQYG 196_ AVRTP 201_ YTMSY 206_ GDSLY 211_ YNNAY 216_ GALDA 221_ YYKRC 226_ RAARS 231_ YEAVA 236_ AAAAS 241_ VYNYA 246_ EQTLS 251_ QLPQV 256_ QNTAM 261_ ASHLT 266_ STSLD 271_ PYDRH 276_ LLPTS 281_ GAAAT 286_ AAAAA 291_ AAAAA 296_ VTAAS 301_ TSYYG 306_ RDRSP 311_ LRRAT 316_ APVPT 321_ VGEGY 326_ GYGHE 331_ SELSQ 336_ ASAAA 341_ RNSLY 346_ DMARY 351_ EREQY 356_ADRAR
1: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro