FUN14 domain-containing protein 2 (Cervical cancer proto-oncogene 3 protein) (HCC-3) (Hepatitis C virus core-binding protein 6)
1_METSA 6_ PRAGS 11_ QVVAT 16_ TARHS 21_ AAYRA 26_ DPLRV 31_ SSRDK 36_ LTEMA 41_ ASSQG 46_ NFEGN 51_ FESLD 56_ LAEFA 61_ KKQPW 66_ WRKLF 71_ GQESG 76_ PSAEK 81_ YSVAT 86_ QLFIG 91_ GVTGW 96_ CTGFI 101_ FQKVG 106_ KLAAT 111_ AVGGG 116_ FFLLQ 121_ LANHT 126_ GYIKV 131_ DWQRV 136_ EKDMK 141_ KAKEQ 146_ LKIRK 151_ SNQIP 156_ TEVRS 161_ KAEEV 166_ VSFVK 171_ KNVLV 176_ TGGFF 181_GGFLL
1: Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (PubMed:25855506, PubMed:29187281)