Gene name: SFXN3

Uniprot entry:

Q9BWM7

Protein names:

Sideroflexin-3

Protein sequence:

1_MGELP 6_ LDINI 11_ QEPRW 16_ DQSTF 21_ LGRAR 26_ HFFTV 31_ TDPRN 36_ LLLSG 41_ AQLEA 46_ SRNIV 51_ QNYRA 56_ GVVTP 61_ GITED 66_ QLWRA 71_ KYVYD 76_ SAFHP 81_ DTGEK 86_ VVLIG 91_ RMSAQ 96_ VPMNM 101_ TITGC 106_ MLTFY 111_ RKTPT 116_ VVFWQ 121_ WVNQS 126_ FNAIV 131_ NYSNR 136_ SGDTP 141_ ITVRQ 146_ LGTAY 151_ VSATT 156_ GAVAT 161_ ALGLK 166_ SLTKH 171_ LPPLV 176_ GRFVP 181_ FAAVA 186_ AANCI 191_ NIPLM 196_ RQREL 201_ QVGIP 206_ VADEA 211_ GQRLG 216_ YSVTA 221_ AKQGI 226_ FQVVI 231_ SRICM 236_ AIPAM 241_ AIPPL 246_ IMDTL 251_ EKKDF 256_ LKRRP 261_ WLGAP 266_ LQVGL 271_ VGFCL 276_ VFATP 281_ LCCAL 286_ FPQKS 291_ SIHIS 296_ NLEPE 301_ LRAQI 306_ HEQNP 311_ SVEVV 316_YYNKG

Protein annotations

Protein functions:

1: Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (PubMed:30442778). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778)