Collectin-11 (Collectin kidney protein 1) (CL-K1)
1_MRGNL 6_ ALVGV 11_ LISLA 16_ FLSLL 21_ PSGHP 26_ QPAGD 31_ DACSV 36_ QILVP 41_ GLKGD 46_ AGEKG 51_ DKGAP 56_ GRPGR 61_ VGPTG 66_ EKGDM 71_ GDKGQ 76_ KGSVG 81_ RHGKI 86_ GPIGS 91_ KGEKG 96_ DSGDI 101_ GPPGP 106_ NGEPG 111_ LPCEC 116_ SQLRK 121_ AIGEM 126_ DNQVS 131_ QLTSE 136_ LKFIK 141_ NAVAG 146_ VRETE 151_ SKIYL 156_ LVKEE 161_ KRYAD 166_ AQLSC 171_ QGRGG 176_ TLSMP 181_ KDEAA 186_ NGLMA 191_ AYLAQ 196_ AGLAR 201_ VFIGI 206_ NDLEK 211_ EGAFV 216_ YSDHS 221_ PMRTF 226_ NKWRS 231_ GEPNN 236_ AYDEE 241_ DCVEM 246_ VASGG 251_ WNDVA 256_ CHTTM 261_ YFMCE 266_FDKEN
1: Lectin that plays a role in innate immunity, apoptosis and embryogenesis (PubMed:21258343, PubMed:23954398, PubMed:25912189). Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope (PubMed:25912189). Primarily recognizes the terminal disaccharide of the glycan (PubMed:25912189). Also recognizes a subset of fucosylated glycans and lipopolysaccharides (PubMed:17179669, PubMed:25912189). Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 (PubMed:20956340, PubMed:25912189). Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis (PubMed:21258343, PubMed:28301481)