Probable tubulin polyglutamylase TTLL2 (EC 6.-.-.-) (Testis-specific protein NYD-TSPG) (Tubulin--tyrosine ligase-like protein 2)
1_MRGRD 6_ LCSST 11_ QSQAL 16_ GSLRT 21_ TTPAF 26_ TLNIP 31_ SEANH 36_ TEQPP 41_ AGLGA 46_ RLQEA 51_ GVSIP 56_ PRRGR 61_ PTPTL 66_ EKKKK 71_ PHLMA 76_ EDEPS 81_ GALLK 86_ PLVFR 91_ VDETT 96_ PAVVQ 101_ SVLLE 106_ RGWNK 111_ FDKQE 116_ QNAED 121_ WNLYW 126_ RTSSF 131_ RMTEH 136_ NSVKP 141_ WQQLN 146_ HHPGT 151_ TKLTR 156_ KDCLA 161_ KHLKH 166_ MRRMY 171_ GTSLY 176_ QFIPL 181_ TFVMP 186_ NDYTK 191_ FVAEY 196_ FQERQ 201_ MLGTK 206_ HSYWI 211_ CKPAE 216_ LSRGR 221_ GILIF 226_ SDFKD 231_ FIFDD 236_ MYIVQ 241_ KYISN 246_ PLLIG 251_ RYKCD 256_ LRIYV 261_ CVTGF 266_ KPLTI 271_ YVYQE 276_ GLVRF 281_ ATEKF 286_ DLSNL 291_ QNNYA 296_ HLTNS 301_ SINKS 306_ GASYE 311_ KIKEV 316_ IGHGC 321_ KWTLS 326_ RFFSY 331_ LRSWD 336_ VDDLL 341_ LWKKI 346_ HRMVI 351_ LTILA 356_ IAPSV 361_ PFAAN 366_ CFELF 371_ GFDIL 376_ IDDNL 381_ KPWLL 386_ EVNYS 391_ PALTL 396_ DCSTD 401_ VLVKR 406_ KLVHD 411_ IIDLI 416_ YLNGL 421_ RNEGR 426_ EASNA 431_ THGNS 436_ NIDAA 441_ KSDRG 446_ GLDAP 451_ DCLPY 456_ DSLSF 461_ TSRMY 466_ NEDDS 471_ VVEKA 476_ VSVRP 481_ EAAPA 486_ SQLEG 491_ EMSGQ 496_ DFHLS 501_ TREMP 506_ QSKPK 511_ LRSRH 516_ TPHKT 521_ LMPYA 526_ SLFQS 531_ HSCKT 536_ KTSPC 541_ VLSDR 546_ GKAPD 551_ PQAGN 556_ FVLVF 561_ PFNEA 566_ TLGAS 571_ RNGLN 576_ VKRII 581_ QELQK 586_LMNKQ
1: Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (By similarity). Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (By similarity). Probably involved in the side-chain initiation step of the polyglutamylation reaction rather than the elongation step (By similarity)