PHD finger protein 7 (Testis development protein NYD-SP6)
1_MKTVK 6_ EKKEC 11_ QRLRK 16_ SAKTR 21_ RVTQR 26_ KPSSG 31_ PVCWL 36_ CLREP 41_ GDPEK 46_ LGEFL 51_ QKDNI 56_ SVHYF 61_ CLILS 66_ SKLPQ 71_ RGQSN 76_ RGFHG 81_ FLPED 86_ IKKEA 91_ ARASR 96_ KICFV 101_ CKKKG 106_ AAINC 111_ QKDQC 116_ LRNFH 121_ LPCGQ 126_ ERGCL 131_ SQFFG 136_ EYKSF 141_ CDKHR 146_ PTQNI 151_ QHGHV 156_ GEESC 161_ ILCCE 166_ DLSQQ 171_ SVENI 176_ QSPCC 181_ SQAIY 186_ HRKCI 191_ QKYAH 196_ TSAKH 201_ FFKCP 206_ QCNNR 211_ KEFPQ 216_ EMLRM 221_ GIHIP 226_ DRDAA 231_ WELEP 236_ GAFSD 241_ LYQRY 246_ QHCDA 251_ PICLY 256_ EQGRD 261_ SFEDE 266_ GRWCL 271_ ILCAT 276_ CGSHG 281_ THRDC 286_ SSLRS 291_ NSKKW 296_ ECEEC 301_ SPAAA 306_ TDYIP 311_ ENSGD 316_ IPCCS 321_ STFHP 326_ EEHFC 331_ RDNTL 336_ EENPG 341_ LSWTD 346_ WPEPS 351_ LLEKP 356_ ESSRG 361_ RRSYS 366_ WRSKG 371_ VRITN 376_SCKKS
1: E3 ubiquitin-protein ligase which ubiquitinates histone H3 at 'Lys-14' (By similarity). Required for male fertility, via inhibition of SPOP-mediated BRDT degradation when in the presence of acetylated histone H4 in early condensing spermatids (By similarity). Stabilization of BRDT allows it to facilitate histone removal in early condensing spermatids and promote the progression of histone-to-protamine exchange (By similarity). Promotes the expression of steroidogenesis proteins in the testes, and as a result plays a role in maintaining testosterone levels and repressing osteoclastogenesis (By similarity). Promotes transcription of cardiac enhancer genes by facilitating binding of cardiac transcription factors such as MEF2C and GATA4 to target gene promoters (By similarity). Ubiquitinates histone H4 (PubMed:32726616). Ubiquitinates histone H2A and H3 as part of the nucleosome core particle (By similarity)