RNA-binding protein 24 (RNA-binding motif protein 24) (RNA-binding region-containing protein 6)
1_MHTTQ 6_ KDTTY 11_ TKIFV 16_ GGLPY 21_ HTTDA 26_ SLRKY 31_ FEVFG 36_ EIEEA 41_ VVITD 46_ RQTGK 51_ SRGYG 56_ FVTMA 61_ DRAAA 66_ ERACK 71_ DPNPI 76_ IDGRK 81_ ANVNL 86_ AYLGA 91_ KPRIM 96_ QPGFA 101_ FGVQQ 106_ LHPAL 111_ IQRPF 116_ GIPAH 121_ YVYPQ 126_ AFVQP 131_ GVVIP 136_ HVQPT 141_ AAAAS 146_ TTPYI 151_ DYTGA 156_ AYAQY 161_ SAAAA 166_ AAAAA 171_ AAYDQ 176_ YPYAA 181_ SPAAA 186_ GYVTA 191_ GGYGY 196_ AVQQP 201_ ITAAA 206_ PGTAA 211_ AAAAA 216_ AAAAA 221_ AFGQY 226_ QPQQL 231_QTDRM
1: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29104163, PubMed:29358667). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed:29104163). Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities (PubMed:20977548, PubMed:24356969). Involved in myogenic differentiation by regulating MYOG levels (PubMed:20977548). Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization (PubMed:24375645). Also promotes the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence (PubMed:29104163). Plays a role in the regulation of mRNA translation (PubMed:29358667). Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation (PubMed:29358667). Binds to a huge amount of mRNAs (PubMed:29104163). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity). Together with RBM20, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity)
2: (Microbial infection) Promotes hepatitis C virus (HCV) replication over translation through the inhibition of viral protein expression. Decreases viral translation by linking viral 5'- and 3'-UTRs, blocking 80S ribosome assembly on the viral IRES and enhancing the interaction of the mature core protein and 5'-UTR