Fanconi anemia group J protein (Protein FACJ) (EC 3.6.4.13) (ATP-dependent RNA helicase BRIP1) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1)
1_MSSMW 6_ SEYTI 11_ GGVKI 16_ YFPYK 21_ AYPSQ 26_ LAMMN 31_ SILRG 36_ LNSKQ 41_ HCLLE 46_ SPTGS 51_ GKSLA 56_ LLCSA 61_ LAWQQ 66_ SLSGK 71_ PADEG 76_ VSEKA 81_ EVQLS 86_ CCCAC 91_ HSKDF 96_ TNNDM 101_ NQGTS 106_ RHFNY 111_ PSTPP 116_ SERNG 121_ TSSTC 126_ QDSPE 131_ KTTLA 136_ AKLSA 141_ KKQAS 146_ IYRDE 151_ NDDFQ 156_ VEKKR 161_ IRPLE 166_ TTQQI 171_ RKRHC 176_ FGTEV 181_ HNLDA 186_ KVDSG 191_ KTVKL 196_ NSPLE 201_ KINSF 206_ SPQKP 211_ PGHCS 216_ RCCCS 221_ TKQGN 226_ SQESS 231_ NTIKK 236_ DHTGK 241_ SKIPK 246_ IYFGT 251_ RTHKQ 256_ IAQIT 261_ RELRR 266_ TAYSG 271_ VPMTI 276_ LSSRD 281_ HTCVH 286_ PEVVG 291_ NFNRN 296_ EKCME 301_ LLDGK 306_ NGKSC 311_ YFYHG 316_ VHKIS 321_ DQHTL 326_ QTFQG 331_ MCKAW 336_ DIEEL 341_ VSLGK 346_ KLKAC 351_ PYYTA 356_ RELIQ 361_ DADII 366_ FCPYN 371_ YLLDA 376_ QIRES 381_ MDLNL 386_ KEQVV 391_ ILDEA 396_ HNIED 401_ CARES 406_ ASYSV 411_ TEVQL 416_ RFARD 421_ ELDSM 426_ VNNNI 431_ RKKDH 436_ EPLRA 441_ VCCSL 446_ INWLE 451_ ANAEY 456_ LVERD 461_ YESAC 466_ KIWSG 471_ NEMLL 476_ TLHKM 481_ GITTA 486_ TFPIL 491_ QGHFS 496_ AVLQK 501_ EEKIS 506_ PIYGK 511_ EEARE 516_ VPVIS 521_ ASTQI 526_ MLKGL 531_ FMVLD 536_ YLFRQ 541_ NSRFA 546_ DDYKI 551_ AIQQT 556_ YSWTN 561_ QIDIS 566_ DKNGL 571_ LVLPK 576_ NKKRS 581_ RQKTA 586_ VHVLN 591_ FWCLN 596_ PAVAF 601_ SDING 606_ KVQTI 611_ VLTSG 616_ TLSPM 621_ KSFSS 626_ ELGVT 631_ FTIQL 636_ EANHI 641_ IKNSQ 646_ VWVGT 651_ IGSGP 656_ KGRNL 661_ CATFQ 666_ NTETF 671_ EFQDE 676_ VGALL 681_ LSVCQ 686_ TVSQG 691_ ILCFL 696_ PSYKL 701_ LEKLK 706_ ERWLS 711_ TGLWH 716_ NLELV 721_ KTVIV 726_ EPQGG 731_ EKTNF 736_ DELLQ 741_ VYYDA 746_ IKYKG 751_ EKDGA 756_ LLVAV 761_ CRGKV 766_ SEGLD 771_ FSDDN 776_ ARAVI 781_ TIGIP 786_ FPNVK 791_ DLQVE 796_ LKRQY 801_ NDHHS 806_ KLRGL 811_ LPGRQ 816_ WYEIQ 821_ AYRAL 826_ NQALG 831_ RCIRH 836_ RNDWG 841_ ALILV 846_ DDRFR 851_ NNPSR 856_ YISGL 861_ SKWVR 866_ QQIQH 871_ HSTFE 876_ SALES 881_ LAEFS 886_ KKHQK 891_ VLNVS 896_ IKDRT 901_ NIQDN 906_ ESTLE 911_ VTSLK 916_ YSTSP 921_ YLLEA 926_ ASHLS 931_ PENFV 936_ EDEAK 941_ ICVQE 946_ LQCPK 951_ IITKN 956_ SPLPS 961_ SIISR 966_ KEKND 971_ PVFLE 976_ EAGKA 981_ EKIVI 986_ SRSTS 991_ PTFNK 996_ QTKRV 1001_ SWSSF 1006_ NSLGQ 1011_ YFTGK 1016_ IPKAT 1021_ PELGS 1026_ SENSA 1031_ SSPPR 1036_ FKTEK 1041_ MESKT 1046_ VLPFT 1051_ DKCES 1056_ SNLTV 1061_ NTSFG 1066_ SCPQS 1071_ ETIIS 1076_ SLKID 1081_ ATLTR 1086_ KNHSE 1091_ HPLCS 1096_ EEALD 1101_ PDIEL 1106_ SLVSE 1111_ EDKQS 1116_ TSNRD 1121_ FETEA 1126_ EDESI 1131_ YFTPE 1136_ LYDPE 1141_ DTDEE 1146_ KNDLA 1151_ ETDRG 1156_ NRLAN 1161_ NSDCI 1166_ LAKDL 1171_ FEIRT 1176_ IKEVD 1181_ SAREV 1186_ KAEDC 1191_ IDTKL 1196_ NGILH 1201_ IEESK 1206_ IDDID 1211_ GNVKT 1216_ TWINE 1221_ LELGK 1226_ THEIE 1231_ IKNFK 1236_ PSPSK 1241_NKGMF
1: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of chromosomal stability (PubMed:11301010, PubMed:14983014, PubMed:16116421, PubMed:16153896, PubMed:17596542, PubMed:36608669). Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination (PubMed:14983014, PubMed:16153896). Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (PubMed:14983014, PubMed:16153896). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (PubMed:16116421, PubMed:36608669). Can unwind RNA:DNA substrates (PubMed:14983014). Unwinds G-quadruplex DNA; unwinding requires a 5'-single stranded tail (PubMed:18426915, PubMed:20639400)