Junctional adhesion molecule C (JAM-C) (JAM-2) (Junctional adhesion molecule 3) (JAM-3) [Cleaved into: Soluble form of JAM-C (sJAM-C)]
1_MALRR 6_ PPRLR 11_ LCARL 16_ PDFFL 21_ LLLFR 26_ GCLIG 31_ AVNLK 36_ SSNRT 41_ PVVQE 46_ FESVE 51_ LSCII 56_ TDSQT 61_ SDPRI 66_ EWKKI 71_ QDEQT 76_ TYVFF 81_ DNKIQ 86_ GDLAG 91_ RAEIL 96_ GKTSL 101_ KIWNV 106_ TRRDS 111_ ALYRC 116_ EVVAR 121_ NDRKE 126_ IDEIV 131_ IELTV 136_ QVKPV 141_ TPVCR 146_ VPKAV 151_ PVGKM 156_ ATLHC 161_ QESEG 166_ HPRPH 171_ YSWYR 176_ NDVPL 181_ PTDSR 186_ ANPRF 191_ RNSSF 196_ HLNSE 201_ TGTLV 206_ FTAVH 211_ KDDSG 216_ QYYCI 221_ ASNDA 226_ GSARC 231_ EEQEM 236_ EVYDL 241_ NIGGI 246_ IGGVL 251_ VVLAV 256_ LALIT 261_ LGICC 266_ AYRRG 271_ YFINN 276_ KQDGE 281_ SYKNP 286_ GKPDG 291_ VNYIR 296_ TDEEG 301_DFRHK
1: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:11590146, PubMed:11823489). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:11590146, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:12208882, PubMed:15194813). Plays a role in angiogenesis (PubMed:23255084). Plays a role in the regulation of cell migration (Probable). During myogenesis, it is involved in myocyte fusion (By similarity)
2: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis