Receptor for retinol uptake STRA6 (Retinol-binding protein receptor STRA6) (Stimulated by retinoic acid gene 6 protein homolog)
1_MSSQP 6_ AGNQT 11_ SPGAT 16_ EDYSY 21_ GSWYI 26_ DEPQG 31_ GEELQ 36_ PEGEV 41_ PSCHT 46_ SIPPG 51_ LYHAC 56_ LASLS 61_ ILVLL 66_ LLAML 71_ VRRRQ 76_ LWPDC 81_ VRGRP 86_ GLPSP 91_ VDFLA 96_ GDRPR 101_ AVPAA 106_ VFMVL 111_ LSSLC 116_ LLLPD 121_ EDALP 126_ FLTLA 131_ SAPSQ 136_ DGKTE 141_ APRGA 146_ WKILG 151_ LFYYA 156_ ALYYP 161_ LAACA 166_ TAGHT 171_ AAHLL 176_ GSTLS 181_ WAHLG 186_ VQVWQ 191_ RAECP 196_ QVPKI 201_ YKYYS 206_ LLASL 211_ PLLLG 216_ LGFLS 221_ LWYPV 226_ QLVRS 231_ FSRRT 236_ GAGSK 241_ GLQSS 246_ YSEEY 251_ LRNLL 256_ CRKKL 261_ GSSYH 266_ TSKHG 271_ FLSWA 276_ RVCLR 281_ HCIYT 286_ PQPGF 291_ HLPLK 296_ LVLSA 301_ TLTGT 306_ AIYQV 311_ ALLLL 316_ VGVVP 321_ TIQKV 326_ RAGVT 331_ TDVSY 336_ LLAGF 341_ GIVLS 346_ EDKQE 351_ VVELV 356_ KHHLW 361_ ALEVC 366_ YISAL 371_ VLSCL 376_ LTFLV 381_ LMRSL 386_ VTHRT 391_ NLRAL 396_ HRGAA 401_ LDLSP 406_ LHRSP 411_ HPSRQ 416_ AIFCW 421_ MSFSA 426_ YQTAF 431_ ICLGL 436_ LVQQI 441_ IFFLG 446_ TTALA 451_ FLVLM 456_ PVLHG 461_ RNLLL 466_ FRSLE 471_ SSWPF 476_ WLTLA 481_ LAVIL 486_ QNMAA 491_ HWVFL 496_ ETHDG 501_ HPQLT 506_ NRRVL 511_ YAATF 516_ LLFPL 521_ NVLVG 526_ AMVAT 531_ WRVLL 536_ SALYN 541_ AIHLG 546_ QMDLS 551_ LLPPR 556_ AATLD 561_ PGYYT 566_ YRNFL 571_ KIEVS 576_ QSHPA 581_ MTAFC 586_ SLLLQ 591_ AQSLL 596_ PRTMA 601_ APQDS 606_ LRPGE 611_ EDEGM 616_ QLLQT 621_ KDSMA 626_ KGARP 631_ GASRG 636_ RARWG 641_ LAYTL 646_ LHNPT 651_ LQVFR 656_ KTALL 661_GANGA
1: Functions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:18316031, PubMed:22665496, PubMed:9452451). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031)