Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6)
1_MKEQP 6_ VLERL 11_ QSQKS 16_ WIKGV 21_ FDKRE 26_ CSTII 31_ PSSKN 36_ PHRCT 41_ PVCQV 46_ CQNLI 51_ RCYCG 56_ RLIGD 61_ HAGID 66_ YSWTI 71_ SAAKG 76_ KESEQ 81_ WSVEK 86_ HTTKS 91_ PTDTF 96_ GTINF 101_ QDGEH 106_ THHAK 111_ YIRTS 116_ YDTKL 121_ DHLLH 126_ LMLKE 131_ WKMEL 136_ PKLVI 141_ SVHGG 146_ IQNFT 151_ MPSKF 156_ KEIFS 161_ QGLVK 166_ AAETT 171_ GAWII 176_ TEGIN 181_ TGVSK 186_ HVGDA 191_ LKSHS 196_ SHSLR 201_ KIWTV 206_ GIPPW 211_ GVIEN 216_ QRDLI 221_ GKDVV 226_ CLYQT 231_ LDNPL 236_ SKLTT 241_ LNSMH 246_ SHFIL 251_ SDDGT 256_ VGKYG 261_ NEMKL 266_ RRNLE 271_ KYLSL 276_ QKIHC 281_ RSRQG 286_ VPVVG 291_ LVVEG 296_ GPNVI 301_ LSVWE 306_ TVKDK 311_ DPVVV 316_ CEGTG 321_ RAADL 326_ LAFTH 331_ KHLAD 336_ EGMLR 341_ PQVKE 346_ EIICM 351_ IQNTF 356_ NFSLK 361_ QSKHL 366_ FQILM 371_ ECMVH 376_ RDCIT 381_ IFDAD 386_ SEEQQ 391_ DLDLA 396_ ILTAL 401_ LKGTN 406_ LSASE 411_ QLNLA 416_ MAWDR 421_ VDIAK 426_ KHILI 431_ YEQHW 436_ KPDAL 441_ EQAMS 446_ DALVM 451_ DRVDF 456_ VKLLI 461_ EYGVN 466_ LHRFL 471_ TIPRL 476_ EELYN 481_ TKQGP 486_ TNTLL 491_ HHLVQ 496_ DVKQH 501_ TLLSG 506_ YRITL 511_ IDIGL 516_ VVEYL 521_ IGRAY 526_ RSNYT 531_ RKHFR 536_ ALYNN 541_ LYRKY 546_ KHQRH 551_ SSGNR 556_ NESAE 561_ STLHS 566_ QFIRT 571_ AQPYK 576_ FKEKS 581_ IVLHK 586_ SRKKS 591_ KEQNV 596_ SDDPE 601_ STGFL 606_ YPYND 611_ LLVWA 616_ VLMKR 621_ QKMAM 626_ FFWQH 631_ GEEAT 636_ VKAVI 641_ ACILY 646_ RAMAH 651_ EAKES 656_ HMVDD 661_ ASEEL 666_ KNYSK 671_ QFGQL 676_ ALDLL 681_ EKAFK 686_ QNERM 691_ AMTLL 696_ TYELR 701_ NWSNS 706_ TCLKL 711_ AVSGG 716_ LRPFV 721_ SHTCT 726_ QMLLT 731_ DMWMG 736_ RLKMR 741_ KNSWL 746_ KIIIS 751_ IILPP 756_ TILTL 761_ EFKSK 766_ AEMSH 771_ VPQSQ 776_ DFQFM 781_ WYYSD 786_ QNASS 791_ SKESA 796_ SVKEY 801_ DLERG 806_ HDEKL 811_ DENQH 816_ FGLES 821_ GHQHL 826_ PWTRK 831_ VYEFY 836_ SAPIV 841_ KFWFY 846_ TMAYL 851_ AFLML 856_ FTYTV 861_ LVEMQ 866_ PQPSV 871_ QEWLV 876_ SIYIF 881_ TNAIE 886_ VVREI 891_ CISEP 896_ GKFTQ 901_ KVKVW 906_ ISEYW 911_ NLTET 916_ VAIGL 921_ FSAGF 926_ VLRWG 931_ DPPFH 936_ TAGRL 941_ IYCID 946_ IIFWF 951_ SRLLD 956_ FFAVN 961_ QHAGP 966_ YVTMI 971_ AKMTA 976_ NMFYI 981_ VIIMA 986_ IVLLS 991_ FGVAR 996_ KAILS 1001_ PKEPP 1006_ SWSLA 1011_ RDIVF 1016_ EPYWM 1021_ IYGEV 1026_ YAGEI 1031_ DVCSS 1036_ QPSCP 1041_ PGSFL 1046_ TPFLQ 1051_ AVYLF 1056_ VQYII 1061_ MVNLL 1066_ IAFFN 1071_ NVYLD 1076_ MESIS 1081_ NNLWK 1086_ YNRYR 1091_ YIMTY 1096_ HEKPW 1101_ LPPPL 1106_ ILLSH 1111_ VGLLL 1116_ RRLCC 1121_ HRAPH 1126_ DQEEG 1131_ DVGLK 1136_ LYLSK 1141_ EDLKK 1146_ LHDFE 1151_ EQCVE 1156_ KYFHE 1161_ KMEDV 1166_ NCSCE 1171_ ERIRV 1176_ TSERV 1181_ TEMYF 1186_ QLKEM 1191_ NEKVS 1196_ FIKDS 1201_ LLSLD 1206_ SQVGH 1211_ LQDLS 1216_ ALTVD 1221_ TLKVL 1226_ SAVDT 1231_ LQEDE 1236_ ALLAK 1241_ RKHST 1246_ CKKLP 1251_ HSWSN 1256_ VICAE 1261_ VLGSM 1266_ EIAGE 1271_ KKYQY 1276_ YSMPS 1281_ SLLRS 1286_ LAGGR 1291_ HPPRV 1296_ QRGAL 1301_ LEITN 1306_ SKREA 1311_ TNVRN 1316_ DQERQ 1321_ ETQSS 1326_ IVVSG 1331_ VSPNR 1336_ QAHSK 1341_ YGQFL 1346_ LVPSN 1351_ LKRVP 1356_ FSAET 1361_ VLPLS 1366_ RPSVP 1371_ DVLAT 1376_ EQDIQ 1381_ TEVLV 1386_ HLTGQ 1391_ TPVVS 1396_ DWASV 1401_ DEPKE 1406_ KHEPI 1411_ AHLLD 1416_ GQDKA 1421_ EQVLP 1426_ TLSCT 1431_ PEPMT 1436_ MSSPL 1441_ SQAKI 1446_ MQTGG 1451_ GYVNW 1456_ AFSEG 1461_ DETGV 1466_ FSIKK 1471_ KWQTC 1476_ LPSTC 1481_ DSDSS 1486_ RSEQH 1491_ QKQAQ 1496_ DSSLS 1501_ DNSTR 1506_ SAQSS 1511_ ECSEV 1516_ GPWLQ 1521_ PNTSF 1526_ WINPL 1531_ RRYRP 1536_ FARSH 1541_ SFRFH 1546_ KEEKL 1551_ MKICK 1556_ IKNLS 1561_ GSSEI 1566_ GQGAW 1571_ VKAKM 1576_ LTKDR 1581_ RLSKK 1586_ KKNTQ 1591_ GLQVP 1596_ IITVN 1601_ ACSQS 1606_ DQLNP 1611_ EPGEN 1616_ SISEE 1621_ EYSKN 1626_ WFTVS 1631_ KFSHT 1636_ GVEPY 1641_ IHQKM 1646_ KTKEI 1651_ GQCAI 1656_ QISDY 1661_ LKQSQ 1666_ EDLSK 1671_ NSLWN 1676_ SRSTN 1681_ LNRNS 1686_ LLKSS 1691_ IGVDK 1696_ ISASL 1701_ KSPQE 1706_ PHHHY 1711_ SAIER 1716_ NNLMR 1721_ LSQTI 1726_ PFTPV 1731_ QLFAG 1736_ EEITV 1741_ YRLEE 1746_ SSPLN 1751_ LDKSM 1756_ SSWSQ 1761_ RGRAA 1766_ MIQVL 1771_ SREEM 1776_ DGGLR 1781_ KAMRV 1786_ VSTWS 1791_ EDDIL 1796_ KPGQV 1801_ FIVKS 1806_ FLPEV 1811_ VRTWH 1816_ KIFQE 1821_ STVLH 1826_ LCLRE 1831_ IQQQR 1836_ AAQKL 1841_ IYTFN 1846_ QVKPQ 1851_ TIPYT 1856_ PRFLE 1861_ VFLIY 1866_ CHSAN 1871_ QWLTI 1876_ EKYMT 1881_ GEFRK 1886_ YNNNN 1891_ GDEIT 1896_ PTNTL 1901_ EELML 1906_ AFSHW 1911_ TYEYT 1916_ RGELL 1921_ VLDLQ 1926_ GVGEN 1931_ LTDPS 1936_ VIKPE 1941_ VKQSR 1946_ GMVFG 1951_ PANLG 1956_ EDAIR 1961_ NFIAK 1966_ HHCNS 1971_ CCRKL 1976_ KLPDL 1981_ KRNDY 1986_ SPERI 1991_ NSTFG 1996_ LEIKI 2001_ ESAEE 2006_ PPARE 2011_ TGRNS 2016_PEDDM
1: Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain (PubMed:14576148, PubMed:16636202, PubMed:18258429, PubMed:18365021). Crucial for Mg(2+) homeostasis. Has an important role in epithelial Mg(2+) transport and in the active Mg(2+) absorption in the gut and kidney (PubMed:14576148). However, whether TRPM6 forms functional homomeric channels by itself or functions primarily as a subunit of heteromeric TRPM6-TRPM7 channels, is still under debate (PubMed:14576148, PubMed:16636202, PubMed:24385424)
2: The C-terminal kinase domain can be cleaved from the channel segment in a cell-type-specific fashion. The cleaved kinase fragments can translocate to the nucleus, and bind chromatin-remodeling complex proteins to ultimately phosphorylate specific Ser/Thr residues of histones known to be functionally important for cell differentiation and development