Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48)
1_MPGPL 6_ GLLCF 11_ LALGL 16_ LGSAG 21_ PSGAA 26_ PPLCA 31_ APCSC 36_ DGDRR 41_ VDCSG 46_ KGLTA 51_ VPEGL 56_ SAFTQ 61_ ALDIS 66_ MNNIT 71_ QLPED 76_ AFKNF 81_ PFLEE 86_ LQLAG 91_ NDLSF 96_ IHPKA 101_ LSGLK 106_ ELKVL 111_ TLQNN 116_ QLKTV 121_ PSEAI 126_ RGLSA 131_ LQSLR 136_ LDANH 141_ ITSVP 146_ EDSFE 151_ GLVQL 156_ RHLWL 161_ DDNSL 166_ TEVPV 171_ HPLSN 176_ LPTLQ 181_ ALTLA 186_ LNKIS 191_ SIPDF 196_ AFTNL 201_ SSLVV 206_ LHLHN 211_ NKIRS 216_ LSQHC 221_ FDGLD 226_ NLETL 231_ DLNYN 236_ NLGEF 241_ PQAIK 246_ ALPSL 251_ KELGF 256_ HSNSI 261_ SVIPD 266_ GAFDG 271_ NPLLR 276_ TIHLY 281_ DNPLS 286_ FVGNS 291_ AFHNL 296_ SDLHS 301_ LVIRG 306_ ASMVQ 311_ QFPNL 316_ TGTVH 321_ LESLT 326_ LTGTK 331_ ISSIP 336_ NNLCQ 341_ EQKML 346_ RTLDL 351_ SYNNI 356_ RDLPS 361_ FNGCH 366_ ALEEI 371_ SLQRN 376_ QIYQI 381_ KEGTF 386_ QGLIS 391_ LRILD 396_ LSRNL 401_ IHEIH 406_ SRAFA 411_ TLGPI 416_ TNLDV 421_ SFNEL 426_ TSFPT 431_ EGLNG 436_ LNQLK 441_ LVGNF 446_ KLKEA 451_ LAAKD 456_ FVNLR 461_ SLSVP 466_ YAYQC 471_ CAFWG 476_ CDSYA 481_ NLNTE 486_ DNSLQ 491_ DHSVA 496_ QEKGT 501_ ADAAN 506_ VTSTL 511_ ENEEH 516_ SQIII 521_ HCTPS 526_ TGAFK 531_ PCEYL 536_ LGSWM 541_ IRLTV 546_ WFIFL 551_ VALFF 556_ NLLVI 561_ LTTFA 566_ SCTSL 571_ PSSKL 576_ FIGLI 581_ SVSNL 586_ FMGIY 591_ TGILT 596_ FLDAV 601_ SWGRF 606_ AEFGI 611_ WWETG 616_ SGCKV 621_ AGFLA 626_ VFSSE 631_ SAIFL 636_ LMLAT 641_ VERSL 646_ SAKDI 651_ MKNGK 656_ SNHLK 661_ QFRVA 666_ ALLAF 671_ LGATV 676_ AGCFP 681_ LFHRG 686_ EYSAS 691_ PLCLP 696_ FPTGE 701_ TPSLG 706_ FTVTL 711_ VLLNS 716_ LAFLL 721_ MAVIY 726_ TKLYC 731_ NLEKE 736_ DLSEN 741_ SQSSM 746_ IKHVA 751_ WLIFT 756_ NCIFF 761_ CPVAF 766_ FSFAP 771_ LITAI 776_ SISPE 781_ IMKSV 786_ TLIFF 791_ PLPAC 796_ LNPVL 801_ YVFFN 806_ PKFKE 811_ DWKLL 816_ KRRVT 821_ KKSGS 826_ VSVSI 831_ SSQGG 836_ CLEQD 841_ FYYDC 846_ GMYSH 851_ LQGNL 856_ TVCDC 861_ CESFL 866_ LTKPV 871_ SCKHL 876_ IKSHS 881_ CPALA 886_ VASCQ 891_ RPEGY 896_ WSDCG 901_ TQSAH 906_ SDYAD 911_ EEDSF 916_ VSDSS 921_ DQVQA 926_ CGRAC 931_ FYQSR 936_ GFPLV 941_ RYAYN 946_LPRVK
1: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity). Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (By similarity)