Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11)
1_MQGGE 6_ PVSTM 11_ KVSES 16_ EGKLE 21_ GQATA 26_ VTPNK 31_ NSSCG 36_ GGISS 41_ SSSSR 46_ GGSAK 51_ GWQYS 56_ DHMEN 61_ VYGYL 66_ MKYTN 71_ LVTGW 76_ QYRFF 81_ VLNNE 86_ AGLLE 91_ YFVNE 96_ QSRNQ 101_ KPRGT 106_ LQLAG 111_ AVISP 116_ SDEDS 121_ HTFTV 126_ NAASG 131_ EQYKL 136_ RATDA 141_ KERQH 146_ WVSRL 151_ QICTQ 156_ HHTEA 161_ IGKNN 166_ PPLKS 171_ RSFSL 176_ ASSSN 181_ SPISQ 186_ RRPSQ 191_ NAISF 196_ FNVGH 201_ SKLQS 206_ LSKRT 211_ NLPPD 216_ HLVEV 221_ REMMS 226_ HAEGQ 231_ QRDLI 236_ RRIEC 241_ LPTSG 246_ HLSSL 251_ DQDLL 256_ MLKAT 261_ SMATM 266_ NCLND 271_ CFHIL 276_ QLQHA 281_ SHQKG 286_ SLPSG 291_ TTIEW 296_ LEPKI 301_ SLSNH 306_ YKNGA 311_ DQPFA 316_ TDQSK 321_ PVAVP 326_ EEQPV 331_ AESGL 336_ LAREP 341_ EEINA 346_ DDEIE 351_ DTCDH 356_ KEDDL 361_ GAVEE 366_ QRSVI 371_ LHLLS 376_ QLKLG 381_ MDLTR 386_ VVLPT 391_ FILEK 396_ RSLLE 401_ MYADF 406_ MSHPD 411_ LFIAI 416_ TNGAT 421_ AEDRM 426_ IRFVE 431_ YYLTS 436_ FHEGR 441_ KGAIA 446_ KKPYN 451_ PIIGE 456_ TFHCS 461_ WKMPK 466_ SEVAS 471_ SVFSS 476_ SSTQG 481_ VTNHA 486_ PLSGE 491_ SLTQV 496_ GSDCY 501_ TVRFV 506_ AEQVS 511_ HHPPV 516_ SGFYA 521_ ECTER 526_ KMCVN 531_ AHVWT 536_ KSKFL 541_ GMSIG 546_ VTMVG 551_ EGILS 556_ LLEHG 561_ EEYTF 566_ SLPCA 571_ YARSI 576_ LTVPW 581_ VELGG 586_ KVSVN 591_ CAKTG 596_ YSASI 601_ TFHTK 606_ PFYGG 611_ KLHRV 616_ TAEVK 621_ HNITN 626_ TVVCR 631_ VQGEW 636_ NSVLE 641_ FTYSN 646_ GETKY 651_ VDLTK 656_ LAVTK 661_ KRVRP 666_ LEKQD 671_ PFESR 676_ RLWKN 681_ VTDSL 686_ RESEI 691_ DKATE 696_ HKHTL 701_ EERQR 706_ TEERH 711_ RTETG 716_ TPWKT 721_ KYFIK 726_ EGDGW 731_ VYHKP 736_ LWKII 741_PTTQP
1: Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage (PubMed:23028956). Weakly binds 25-hydroxycholesterol (PubMed:17428193). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:39106189). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:39106189)