Bcl-2-binding component 3, isoforms 1/2 (JFY-1) (p53 up-regulated modulator of apoptosis)
1_MARAR 6_ QEGSS 11_ PEPVE 16_ GLARD 21_ GPRPF 26_ PLGRL 31_ VPSAV 36_ SCGLC 41_ EPGLA 46_ AAPAA 51_ PTLLP 56_ AAYLC 61_ APTAP 66_ PAVTA 71_ ALGGS 76_ RWPGG 81_ PRSRP 86_ RGPRP 91_ DGPQP 96_ SLSLA 101_ EQHLE 106_ SPVPS 111_ APGAL 116_ AGGPT 121_ QAAPG 126_ VRGEE 131_ EQWAR 136_ EIGAQ 141_ LRRMA 146_ DDLNA 151_ QYERR 156_ RQEEQ 161_ QRHRP 166_ SPWRV 171_ LYNLI 176_ MGLLP 181_ LPRGH 186_RAPEM
1: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity)