Complement C1q tumor necrosis factor-related protein 4 (C1q/TNF-related protein 4)
1_MLPLL 6_ LGLLG 11_ PAACW 16_ ALGPT 21_ PGPGS 26_ SELRS 31_ AFSAA 36_ RTTPL 41_ EGTSE 46_ MAVTF 51_ DKVYV 56_ NIGGD 61_ FDVAT 66_ GQFRC 71_ RVPGA 76_ YFFSF 81_ TAGKA 86_ PHKSL 91_ SVMLV 96_ RNRDE 101_ VQALA 106_ FDEQR 111_ RPGAR 116_ RAASQ 121_ SAMLQ 126_ LDYGD 131_ TVWLR 136_ LHGAP 141_ QYALG 146_ APGAT 151_ FSGYL 156_ VYADA 161_ DADAP 166_ ARGPP 171_ APPEP 176_ RSAFS 181_ AARTR 186_ SLVGS 191_ DAGPG 196_ PRHQP 201_ LAFDT 206_ EFVNI 211_ GGDFD 216_ AAAGV 221_ FRCRL 226_ PGAYF 231_ FSFTL 236_ GKLPR 241_ KTLSV 246_ KLMKN 251_ RDEVQ 256_ AMIYD 261_ DGASR 266_ RREMQ 271_ SQSVM 276_ LALRR 281_ GDAVW 286_ LLSHD 291_ HDGYG 296_ AYSNH 301_ GKYIT 306_ FSGFL 311_ VYPDL 316_ APAAP 321_PGLGA
1: May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent (PubMed:21658842, PubMed:27086950). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 hours post-injection (By similarity)