Ion channel TACAN (Transmembrane protein 120A) (Transmembrane protein induced by tumor necrosis factor alpha)
1_MQPPP 6_ PGPLG 11_ DCLRD 16_ WEDLQ 21_ QDFQN 26_ IQETH 31_ RLYRL 36_ KLEEL 41_ TKLQN 46_ NCTSS 51_ ITRQK 56_ KRLQE 61_ LALAL 66_ KKCKP 71_ SLPAE 76_ AEGAA 81_ QELEN 86_ QMKER 91_ QGLFF 96_ DMEAY 101_ LPKKN 106_ GLYLS 111_ LVLGN 116_ VNVTL 121_ LSKQA 126_ KFAYK 131_ DEYEK 136_ FKLYL 141_ TIILI 146_ LISFT 151_ CRFLL 156_ NSRVT 161_ DAAFN 166_ FLLVW 171_ YYCTL 176_ TIRES 181_ ILINN 186_ GSRIK 191_ GWWVF 196_ HHYVS 201_ TFLSG 206_ VMLTW 211_ PDGLM 216_ YQKFR 221_ NQFLS 226_ FSMYQ 231_ SFVQF 236_ LQYYY 241_ QSGCL 246_ YRLRA 251_ LGERH 256_ TMDLT 261_ VEGFQ 266_ SWMWR 271_ GLTFL 276_ LPFLF 281_ FGHFW 286_ QLFNA 291_ LTLFN 296_ LAQDP 301_ QCKEW 306_ QVLMC 311_ GFPFL 316_ LLFLG 321_ NFFTT 326_ LRVVH 331_ HKFHS 336_QRHGS
1: Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism and adipocyte differentiation (PubMed:26024229, PubMed:36420836). May function as a potential ion channel involved in sensing mechanical stimuli (PubMed:35235791). Mediates the mechanosensitivity of the PKD2-TMEM120A channel complex through direct physical interaction (PubMed:36420836). TMEM120A seems to affect mechanosensation by inhibiting PIEZO2 channels, possibly by altering cellular lipid content (By similarity). TMEM120A is structurally similar to a lipid-modifying enzyme, ELOVL7, and contains a bound coenzyme A molecule, which suggests it might function as an enzyme in lipid metabolism (PubMed:34374645, PubMed:34409941, PubMed:34465718). Additionnaly, implicated in innate immune response against Zika virus. Acts as a key activator of the antiviral signaling involving STING1 (PubMed:35013224)