Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2)
1_MGELC 6_ RRDSA 11_ LTALD 16_ EETLW 21_ EMMES 26_ HRHRI 31_ VRCIC 36_ PSRLT 41_ PYLRQ 46_ AKVLC 51_ QLDEE 56_ EVLHS 61_ PRLTN 66_ SAMRA 71_ GHLLD 76_ LLKTR 81_ GKNGA 86_ IAFLE 91_ SLKFH 96_ NPDVY 101_ TLVTG 106_ LQPDV 111_ DFSNF 116_ SGLME 121_ TSKLT 126_ ECLAG 131_ AIGSL 136_ QEELN 141_ QEKGQ 146_ KEVLL 151_ RRCQQ 156_ LQEHL 161_ GLAET 166_ RAEGL 171_ HQLEA 176_ DHSRM 181_ KREVS 186_ AHFHE 191_ VLRLK 196_ DEMLS 201_ LSLHY 206_ SNALQ 211_ EKELA 216_ ASRCR 221_ SLQEE 226_ LYLLK 231_ QELQR 236_ ANMVS 241_ SCELE 246_ LQEQS 251_ LRTAS 256_ DQESG 261_ DEELN 266_ RLKEE 271_ NEKLR 276_ SLTFS 281_ LAEKD 286_ ILEQS 291_ LDEAR 296_ GSRQE 301_ LVERI 306_ HSLRE 311_ RAVAA 316_ ERQRE 321_ QYWEE 326_ KEQTL 331_ LQFQK 336_ SKMAC 341_ QLYRE 346_ KVNAL 351_ QAQVC 356_ ELQKE 361_ RDQAY 366_ SARDS 371_ AQREI 376_ SQSLV 381_ EKDSL 386_ RRQVF 391_ ELTDQ 396_ VCELR 401_ TQLRQ 406_ LQAEP 411_ PGVLK 416_ QEART 421_ REPCP 426_ REKQR 431_ LVRMH 436_ AICPR 441_ DDSDC 446_ SLVSS 451_ TESQL 456_ LSDLS 461_ ATSSR 466_ ELVDS 471_ FRSSS 476_ PAPPS 481_ QQSLY 486_ KRVAE 491_ DFGEE 496_ PWSFS 501_ SCLEI 506_ PEGDP 511_ GALPG 516_ AKAGD 521_ PHLDY 526_ ELLDT 531_ ADLPQ 536_ LESSL 541_ QPVSP 546_ GRLDV 551_ SESGV 556_ LMRRR 561_ PARRI 566_ LSQVT 571_ MLAFQ 576_ GDALL 581_ EQISV 586_ IGGNL 591_ TGIFI 596_ HRVTP 601_ GSAAD 606_ QMALR 611_ PGTQI 616_ VMVDY 621_ EASEP 626_ LFKAV 631_ LEDTT 636_ LEEAV 641_ GLLRR 646_ VDGFC 651_ CLSVK 656_ VNTDG 661_ YKRLL 666_ QDLEA 671_ KVATS 676_ GDSFY 681_ IRVNL 686_ AMEGR 691_ AKGEL 696_ QVHCN 701_ EVLHV 706_ TDTMF 711_ QGCGC 716_ WHAHR 721_ VNSYT 726_ MKDTA 731_ AHGTI 736_ PNYSR 741_ AQQQL 746_ IALIQ 751_ DMTQQ 756_ CTVTR 761_ KPSSG 766_ GPQKL 771_ VRIVS 776_ MDKAK 781_ ASPLR 786_ LSFDR 791_ GQLDP 796_ SRMEG 801_ SSTCF 806_ WAESC 811_ LTLVP 816_ YTLVR 821_ PHRPA 826_ RPRPV 831_ LLVPR 836_ AVGKI 841_ LSEKL 846_ CLLQG 851_ FKKCL 856_ AEYLS 861_ QEEYE 866_ AWSQR 871_ GDIIQ 876_ EGEVS 881_ GGRCW 886_ VTRHA 891_ VESLM 896_ EKNTH 901_ ALLDV 906_ QLDSV 911_ CTLHR 916_ MDIFP 921_ IVIHV 926_ SVNEK 931_ MAKKL 936_ KKGLQ 941_ RLGTS 946_ EEQLL 951_ EAARQ 956_ EEGDL 961_ DRAPC 966_ LYSSL 971_ APDGW 976_ SDLDG 981_ LLSCV 986_ RQAIA 991_ DEQKK 996_VVWTE
1: Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27071417, PubMed:27113748). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis
2: Not able to activate the inflammatory transcription factor NF-kappa-B and may function as a dominant negative regulator (PubMed:21302310, PubMed:26358359)